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Type 2 immunity plays an essential role for murine model of allergic contact dermatitis with mixed type 1/type 2 immune response

DC Field Value Language
dc.contributor.author김태균-
dc.contributor.author박창욱-
dc.contributor.author오종욱-
dc.contributor.author이민걸-
dc.date.accessioned2022-05-09T16:48:26Z-
dc.date.available2022-05-09T16:48:26Z-
dc.date.issued2021-11-
dc.identifier.issn0923-1811-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/188208-
dc.description.abstractBackground: Both human and mouse allergic contact dermatitis (ACD) frequently demonstrates a combined type 1 and type 2 immune response. However, the relative importance of type 2 immunity in this setting has been incompletely understood yet. Objective: To explore an effector function of type 2 immunity in ACD with mixed type 1/type 2 immune response. Methods: Gene expression characteristics of contact hypersensitivity (CHS) model was examined by quantitative polymerase chain reaction. Cytokine profile of T cells was analyzed by flow cytometry. The involvement of type 2 immunity was assessed by antibody-mediated cytokine neutralization and cell depletion. The role of specific subset of cutaneous dendritic cells was evaluated using diphtheria toxin-induced cell-depleting mouse strains. Results: Oxazolone-induced CHS revealed a combination of type 1/type 2 gene expression. The severity of oxazolone-induced CHS was ameliorated by neutralization of IL-4 but not of IFN-γ, indicating that type 2 immunity plays a dominant effector function in this mixed type 1/type 2 model. Mechanistically, type 2 effector immunity was mounted by CD301b+Langeirn- dermal dendritic cells in part through thymic stromal lymphopoietin-interleukin 7 receptor alpha signaling-dependent manner. Conclusion: Our findings suggest the clinical rationale for targeting type 2 immunity as a relevant therapeutic strategy for the mixed immune phenotype of ACD.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfJOURNAL OF DERMATOLOGICAL SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnimals-
dc.subject.MESHAntigens, Surface / metabolism-
dc.subject.MESHDendritic Cells / immunology*-
dc.subject.MESHDermatitis, Allergic Contact / genetics*-
dc.subject.MESHDermatitis, Allergic Contact / immunology*-
dc.subject.MESHDermatitis, Allergic Contact / pathology-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHImmunity / genetics-
dc.subject.MESHImmunoglobulins / metabolism-
dc.subject.MESHInterferon-gamma / genetics-
dc.subject.MESHInterferon-gamma / immunology-
dc.subject.MESHInterleukin-17 / genetics-
dc.subject.MESHInterleukin-4 / genetics-
dc.subject.MESHInterleukin-4 / immunology-
dc.subject.MESHLectins, C-Type / metabolism-
dc.subject.MESHMannose-Binding Lectins / metabolism-
dc.subject.MESHMice-
dc.subject.MESHOxazolone-
dc.subject.MESHReceptors, Cytokine / metabolism-
dc.subject.MESHSignal Transduction-
dc.subject.MESHSkin / pathology-
dc.subject.MESHT-Lymphocytes / metabolism-
dc.subject.MESHTranscriptome-
dc.titleType 2 immunity plays an essential role for murine model of allergic contact dermatitis with mixed type 1/type 2 immune response-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학교실)-
dc.contributor.googleauthorJeyun Park-
dc.contributor.googleauthorJae Won Lee-
dc.contributor.googleauthorSung Hee Kim-
dc.contributor.googleauthorJongwook Oh-
dc.contributor.googleauthorWon Seok Roh-
dc.contributor.googleauthorSoo Min Kim-
dc.contributor.googleauthorChang Ook Park-
dc.contributor.googleauthorMin-Geol Lee-
dc.contributor.googleauthorTae-Gyun Kim-
dc.identifier.doi10.1016/j.jdermsci.2021.10.001-
dc.contributor.localIdA05324-
dc.contributor.localIdA01716-
dc.contributor.localIdA05795-
dc.relation.journalcodeJ01370-
dc.identifier.eissn1873-569X-
dc.identifier.pmid34763990-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0923181121002279-
dc.subject.keywordAllergic contact dermatitis-
dc.subject.keywordContact hypersensitivity-
dc.subject.keywordDendritic cells-
dc.subject.keywordInterleukin-4-
dc.subject.keywordMixed type 1/type 2 immunity-
dc.subject.keywordOxazolone-
dc.subject.keywordT cells-
dc.contributor.alternativeNameKim, Tae-Gyun-
dc.contributor.affiliatedAuthor김태균-
dc.contributor.affiliatedAuthor박창욱-
dc.contributor.affiliatedAuthor오종욱-
dc.citation.volume104-
dc.citation.number2-
dc.citation.startPage122-
dc.citation.endPage131-
dc.identifier.bibliographicCitationJOURNAL OF DERMATOLOGICAL SCIENCE, Vol.104(2) : 122-131, 2021-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

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