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Type 2 immunity plays an essential role for murine model of allergic contact dermatitis with mixed type 1/type 2 immune response
DC Field | Value | Language |
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dc.contributor.author | 김태균 | - |
dc.contributor.author | 박창욱 | - |
dc.contributor.author | 오종욱 | - |
dc.contributor.author | 이민걸 | - |
dc.date.accessioned | 2022-05-09T16:48:26Z | - |
dc.date.available | 2022-05-09T16:48:26Z | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 0923-1811 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188208 | - |
dc.description.abstract | Background: Both human and mouse allergic contact dermatitis (ACD) frequently demonstrates a combined type 1 and type 2 immune response. However, the relative importance of type 2 immunity in this setting has been incompletely understood yet. Objective: To explore an effector function of type 2 immunity in ACD with mixed type 1/type 2 immune response. Methods: Gene expression characteristics of contact hypersensitivity (CHS) model was examined by quantitative polymerase chain reaction. Cytokine profile of T cells was analyzed by flow cytometry. The involvement of type 2 immunity was assessed by antibody-mediated cytokine neutralization and cell depletion. The role of specific subset of cutaneous dendritic cells was evaluated using diphtheria toxin-induced cell-depleting mouse strains. Results: Oxazolone-induced CHS revealed a combination of type 1/type 2 gene expression. The severity of oxazolone-induced CHS was ameliorated by neutralization of IL-4 but not of IFN-γ, indicating that type 2 immunity plays a dominant effector function in this mixed type 1/type 2 model. Mechanistically, type 2 effector immunity was mounted by CD301b+Langeirn- dermal dendritic cells in part through thymic stromal lymphopoietin-interleukin 7 receptor alpha signaling-dependent manner. Conclusion: Our findings suggest the clinical rationale for targeting type 2 immunity as a relevant therapeutic strategy for the mixed immune phenotype of ACD. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | JOURNAL OF DERMATOLOGICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antigens, Surface / metabolism | - |
dc.subject.MESH | Dendritic Cells / immunology* | - |
dc.subject.MESH | Dermatitis, Allergic Contact / genetics* | - |
dc.subject.MESH | Dermatitis, Allergic Contact / immunology* | - |
dc.subject.MESH | Dermatitis, Allergic Contact / pathology | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Immunity / genetics | - |
dc.subject.MESH | Immunoglobulins / metabolism | - |
dc.subject.MESH | Interferon-gamma / genetics | - |
dc.subject.MESH | Interferon-gamma / immunology | - |
dc.subject.MESH | Interleukin-17 / genetics | - |
dc.subject.MESH | Interleukin-4 / genetics | - |
dc.subject.MESH | Interleukin-4 / immunology | - |
dc.subject.MESH | Lectins, C-Type / metabolism | - |
dc.subject.MESH | Mannose-Binding Lectins / metabolism | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Oxazolone | - |
dc.subject.MESH | Receptors, Cytokine / metabolism | - |
dc.subject.MESH | Signal Transduction | - |
dc.subject.MESH | Skin / pathology | - |
dc.subject.MESH | T-Lymphocytes / metabolism | - |
dc.subject.MESH | Transcriptome | - |
dc.title | Type 2 immunity plays an essential role for murine model of allergic contact dermatitis with mixed type 1/type 2 immune response | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학교실) | - |
dc.contributor.googleauthor | Jeyun Park | - |
dc.contributor.googleauthor | Jae Won Lee | - |
dc.contributor.googleauthor | Sung Hee Kim | - |
dc.contributor.googleauthor | Jongwook Oh | - |
dc.contributor.googleauthor | Won Seok Roh | - |
dc.contributor.googleauthor | Soo Min Kim | - |
dc.contributor.googleauthor | Chang Ook Park | - |
dc.contributor.googleauthor | Min-Geol Lee | - |
dc.contributor.googleauthor | Tae-Gyun Kim | - |
dc.identifier.doi | 10.1016/j.jdermsci.2021.10.001 | - |
dc.contributor.localId | A05324 | - |
dc.contributor.localId | A01716 | - |
dc.contributor.localId | A05795 | - |
dc.relation.journalcode | J01370 | - |
dc.identifier.eissn | 1873-569X | - |
dc.identifier.pmid | 34763990 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0923181121002279 | - |
dc.subject.keyword | Allergic contact dermatitis | - |
dc.subject.keyword | Contact hypersensitivity | - |
dc.subject.keyword | Dendritic cells | - |
dc.subject.keyword | Interleukin-4 | - |
dc.subject.keyword | Mixed type 1/type 2 immunity | - |
dc.subject.keyword | Oxazolone | - |
dc.subject.keyword | T cells | - |
dc.contributor.alternativeName | Kim, Tae-Gyun | - |
dc.contributor.affiliatedAuthor | 김태균 | - |
dc.contributor.affiliatedAuthor | 박창욱 | - |
dc.contributor.affiliatedAuthor | 오종욱 | - |
dc.citation.volume | 104 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 122 | - |
dc.citation.endPage | 131 | - |
dc.identifier.bibliographicCitation | JOURNAL OF DERMATOLOGICAL SCIENCE, Vol.104(2) : 122-131, 2021-11 | - |
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