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The triglyceride-glucose index is a more powerful surrogate marker for predicting the prevalence and incidence of type 2 diabetes mellitus than the homeostatic model assessment of insulin resistance

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dc.contributor.author이용제-
dc.contributor.author이혜선-
dc.date.accessioned2022-05-09T16:48:21Z-
dc.date.available2022-05-09T16:48:21Z-
dc.date.issued2021-10-
dc.identifier.issn0168-8227-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/188207-
dc.description.abstractAims: Insulin resistance is an independent risk factor for developing type 2 diabetes. Therefore, this study compared the predictability of the triglyceride-glucose (TyG) index and the homeostatic model assessment of insulin resistance (HOMA-IR) for the prevalence and incidence of type 2 diabetes. Methods: We analyzed data from 9730 adults aged 40-69 years at baseline and 7783 participants without diabetes who were followed up in the Korean Genome and Epidemiology Study survey. From 2001 to 2002 (baseline survey) to 2013-2014, this survey was conducted biennially (six follow-ups). The average follow-up period was 9.0 years. Results: The TyG index showed better predictability for the prevalence of type 2 diabetes than HOMA-IR (TyG index: 0.784, HOMA-IR: 0.728, p < 0.001). The area under the time-dependent receiver operating characteristic curve of the TyG index for incident type 2 diabetes was 0.640 (0.628-0.652), which was significantly higher than that of HOMA-IR [0.531 (0.521-0.541)] (p < 0.001). Conclusions: The TyG index is superior to HOMA-IR for predicting type 2 diabetes. The TyG index could, therefore, be more useful for the early detection and prevention of type 2 diabetes.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier Scientific Publishers-
dc.relation.isPartOfDIABETES RESEARCH AND CLINICAL PRACTICE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBiomarkers-
dc.subject.MESHBlood Glucose-
dc.subject.MESHDiabetes Mellitus, Type 2* / epidemiology-
dc.subject.MESHGlucose-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHInsulin Resistance*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrevalence-
dc.subject.MESHTriglycerides-
dc.titleThe triglyceride-glucose index is a more powerful surrogate marker for predicting the prevalence and incidence of type 2 diabetes mellitus than the homeostatic model assessment of insulin resistance-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Family Medicine (가정의학교실)-
dc.contributor.googleauthorHye Min Park-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorYong-Jae Lee-
dc.contributor.googleauthorJun-Hyuk Lee-
dc.identifier.doi10.1016/j.diabres.2021.109042-
dc.contributor.localIdA02982-
dc.contributor.localIdA03312-
dc.relation.journalcodeJ00723-
dc.identifier.eissn1872-8227-
dc.identifier.pmid34506839-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0168822721004010-
dc.subject.keywordHOMA-IR-
dc.subject.keywordInsulin resistance-
dc.subject.keywordTyG index-
dc.subject.keywordType 2 diabetes-
dc.contributor.alternativeNameLee, Yong Jae-
dc.contributor.affiliatedAuthor이용제-
dc.contributor.affiliatedAuthor이혜선-
dc.citation.volume180-
dc.citation.startPage109042-
dc.identifier.bibliographicCitationDIABETES RESEARCH AND CLINICAL PRACTICE, Vol.180 : 109042, 2021-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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