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Relationship of the lung microbiome with PD-L1 expression and immunotherapy response in lung cancer

 Hye Jin Jang  ;  Ji Yeon Choi  ;  Kangjoon Kim  ;  Seung Hyun Yong  ;  Yeon Wook Kim  ;  Song Yee Kim  ;  Eun Young Kim  ;  Ji Ye Jung  ;  Young Ae Kang  ;  Moo Suk Park  ;  Young Sam Kim  ;  Young-Jae Cho  ;  Sang Hoon Lee 
 RESPIRATORY RESEARCH, Vol.22(1) : 322, 2021-12 
Journal Title
Issue Date
Aged ; Antineoplastic Agents, Immunological ; B7-H1 Antigen / biosynthesis* ; B7-H1 Antigen / genetics ; Biomarkers, Tumor / biosynthesis ; Biomarkers, Tumor / genetics ; Carcinoma, Non-Small-Cell Lung / genetics ; Carcinoma, Non-Small-Cell Lung / metabolism* ; Carcinoma, Non-Small-Cell Lung / therapy ; Female ; Gene Expression Regulation, Neoplastic / physiology* ; Humans ; Immunotherapy / methods* ; Lung / metabolism ; Lung / microbiology ; Lung / pathology ; Lung Neoplasms / genetics ; Lung Neoplasms / metabolism* ; Lung Neoplasms / therapy ; Male ; Microbiota / physiology* ; Middle Aged ; Prospective Studies
Human microbiome ; Lung cancer ; PD-L1 expression levels ; Taxonomy
Background: Lung cancer is the primary cause of cancer-related deaths worldwide. The human lung serves as a niche to a unique and dynamic bacterial community that is related to the development of multiple diseases. Here, we investigated the differences in the lung microbiomes of patients with lung cancer.

Methods: 16S rRNA sequencing was performed to evaluate the respiratory tract microbiome present in the bronchoalveolar lavage fluid. Patients were stratified based on programmed death-ligand 1 (PD-L1) expression levels and immunotherapy responses.

Results: In total, 84 patients were prospectively analyzed, of which 59 showed low (< 10%), and 25 showed high (≥ 10%) PD-L1 expression levels. The alpha and beta diversities did not significantly differ between the two groups. Veillonella dispar was dominant in the high-PD-L1 group; the population of Neisseria was significantly higher in the low-PD-L1 group than in the high-PD-L1 group. In the immunotherapy responder group, V. dispar was dominant, while Haemophilus influenzae and Neisseria perflava were dominant in the non-responder group.

Conclusion: The abundances of Neisseria and V. dispar differed significantly in relation to PD-L1 expression levels and immunotherapy responses.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Young Ae(강영애) ORCID logo https://orcid.org/0000-0002-7783-5271
Kim, Song Yee(김송이) ORCID logo https://orcid.org/0000-0001-8627-486X
Kim, Young Sam(김영삼) ORCID logo https://orcid.org/0000-0001-9656-8482
Kim, Eun Young(김은영) ORCID logo https://orcid.org/0000-0002-3281-5744
Park, Moo Suk(박무석) ORCID logo https://orcid.org/0000-0003-0820-7615
Yong, Seung Hyun(용승현)
Lee, Sang Hoon(이상훈) ORCID logo https://orcid.org/0000-0002-7706-5318
Jang, Hye Jin(장혜진)
Jung, Ji Ye(정지예) ORCID logo https://orcid.org/0000-0003-1589-4142
Choi, Ji Yeon(최지연)
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