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Case Reports of Acute Transverse Myelitis Associated With mRNA Vaccine for COVID-19

Authors
 Hyunjong Eom  ;  Seung Woo Kim  ;  Minkyoung Kim  ;  Ye Eun Kim  ;  Ji Hyun Kim  ;  Ha Young Shin  ;  Hye Lim Lee 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.37(7) : e52, 2022-02 
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN
 1011-8934 
Issue Date
2022-02
MeSH
Aged, 80 and over ; BNT162 Vaccine / adverse effects* ; BNT162 Vaccine / immunology ; COVID-19 / immunology ; Female ; Hand / physiopathology* ; Humans ; Leg / physiopathology* ; Magnetic Resonance Imaging ; Male ; Methylprednisolone / therapeutic use ; Myelitis, Transverse / diagnosis ; Myelitis, Transverse / drug therapy ; Myelitis, Transverse / pathology* ; SARS-CoV-2 / immunology ; Spinal Cord / physiopathology* ; Spine / diagnostic imaging ; Vaccination / adverse effects* ; Young Adult
Keywords
CNS Demyelinating Disease ; COVID-19 Vaccine ; Transverse Myelitis ; mRNA Vaccine
Abstract
Acute transverse myelitis (ATM) has been reported as rare complication of vaccination. Herein, we report 2 cases of ATM after the administration of an mRNA vaccine for coronavirus disease 2019 (COVID-19). The first one is an 81-year-old man who received the BNT162b2 vaccine. He presented with bilateral hand weakness. Spine magnetic resonance imaging (MRI) showed high signal intensity from the C1 to C3 vertebrae. The second is a 23-year-old woman who received the BNT162b2 vaccine and experienced tingling in her legs. Spine MRI showed a high signal intensity lesion at the conus medullaris. These patients were treated with intravenous methylprednisolone and their symptoms improved slightly. Careful follow-up is needed to identify adverse events after the administration of mRNA vaccines for COVID-19.
Files in This Item:
T202200631.pdf Download
DOI
10.3346/jkms.2022.37.e52
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Woo(김승우) ORCID logo https://orcid.org/0000-0002-5621-0811
Shin, Ha Young(신하영) ORCID logo https://orcid.org/0000-0002-4408-8265
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188099
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