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Increased Radiosensitivity of Solid Tumors Harboring ATM and BRCA1/2 Mutations

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dc.contributor.author김경환-
dc.contributor.author김승섭-
dc.contributor.author김한상-
dc.contributor.author심효섭-
dc.contributor.author안중배-
dc.contributor.author윤홍인-
dc.contributor.author이준복-
dc.contributor.author장지석-
dc.contributor.author양지훈-
dc.date.accessioned2022-03-11T06:20:54Z-
dc.date.available2022-03-11T06:20:54Z-
dc.date.issued2022-01-
dc.identifier.issn1598-2998-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/188047-
dc.description.abstractPurpose: Preclinical data indicate that response to radiotherapy (RT) depends on DNA damage repair. In this study, we investigated the role of mutations in genes related to DNA damage repair in treatment outcome after RT. Materials and methods: Patients with solid tumor who participated in next generation sequencing panel screening using biopsied tumor tissue between October 2013 and February 2019 were reviewed and 97 patients that received RT were included in this study. Best response to RT and the cumulative local recurrence rate (LRR) were compared according to absence or presence of missense, nonsense, and frameshift mutations in ATM and/or BRCA1/2. Results: Of the 97 patients, five patients harbored mutation only in ATM, 22 in only BRCA1/2, and six in both ATM and BRCA1/2 (ATMmtBRCAmt). Propensity score matching was performed to select the control group without mutations (ATMwtBRCAwt, n=33). In total, 90 RT-treated target lesions were evaluated in 66 patients. Highest objective response rate of 80% was observed in ATMmtBRCAmt lesions (p=0.007), which was mostly durable. Furthermore, the cumulative 1-year LRR was the lowest in ATMmtBRCAmt lesions and the highest in ATMwtBRCAwt lesions (0% vs. 47.9%, p=0.008). RT-associated toxicities were observed in 10 treatments with no significant difference among the subgroups (p=0.680). Conclusion: Tumors with ATM and BRCA1/2 mutations exhibited superior tumor response and local control after RT compared to tumors without these mutations. The results are hypothesis generating and suggest the need for integrating the tumor mutation profile of DNA repair genes during treatment planning.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish, Korean-
dc.publisherOfficial journal of Korean Cancer Association-
dc.relation.isPartOfCANCER RESEARCH AND TREATMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleIncreased Radiosensitivity of Solid Tumors Harboring ATM and BRCA1/2 Mutations-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학교실)-
dc.contributor.googleauthorKyung Hwan Kim-
dc.contributor.googleauthorHan Sang Kim-
dc.contributor.googleauthorSeung-Seob Kim-
dc.contributor.googleauthorHyo Sup Shim-
dc.contributor.googleauthorAndrew Jihoon Yang-
dc.contributor.googleauthorJason Joon Bock Lee-
dc.contributor.googleauthorHong In Yoon-
dc.contributor.googleauthorJoong Bae Ahn-
dc.contributor.googleauthorJee Suk Chang-
dc.identifier.doi10.4143/crt.2020.1247-
dc.contributor.localIdA05226-
dc.contributor.localIdA05097-
dc.contributor.localIdA01098-
dc.contributor.localIdA02219-
dc.contributor.localIdA02262-
dc.contributor.localIdA04777-
dc.contributor.localIdA05878-
dc.contributor.localIdA04658-
dc.relation.journalcodeJ00453-
dc.identifier.eissn2005-9256-
dc.identifier.pmid34082492-
dc.subject.keywordATM-
dc.subject.keywordBRCA-
dc.subject.keywordDNA repair-
dc.subject.keywordRadiosensitivity-
dc.subject.keywordRadiotherapy-
dc.contributor.alternativeNameKim, Kyung Hwan-
dc.contributor.affiliatedAuthor김경환-
dc.contributor.affiliatedAuthor김승섭-
dc.contributor.affiliatedAuthor김한상-
dc.contributor.affiliatedAuthor심효섭-
dc.contributor.affiliatedAuthor안중배-
dc.contributor.affiliatedAuthor윤홍인-
dc.contributor.affiliatedAuthor이준복-
dc.contributor.affiliatedAuthor장지석-
dc.citation.volume54-
dc.citation.number1-
dc.citation.startPage54-
dc.citation.endPage64-
dc.identifier.bibliographicCitationCANCER RESEARCH AND TREATMENT, Vol.54(1) : 54-64, 2022-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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