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Association of Muscle Strength with Non-Alcoholic Fatty Liver Disease in Korean Adults

Authors
 Sung-Bum Lee  ;  Yu-Jin Kwon  ;  Dong-Hyuk Jung  ;  Jong-Koo Kim 
Citation
 INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, Vol.19(3) : 1675, 2022-02 
Journal Title
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
ISSN
 1661-7827 
Issue Date
2022-02
MeSH
Adult ; Cross-Sectional Studies ; Female ; Hand Strength ; Humans ; Male ; Non-alcoholic Fatty Liver Disease* / complications ; Nutrition Surveys ; Republic of Korea / epidemiology ; Sarcopenia* / complications ; Sarcopenia* / epidemiology
Keywords
NAFLD ; handgrip strength ; sarcopenia
Abstract
Sarcopenia is known to be associated with non-alcoholic fatty liver disease (NAFLD). However, few studies have revealed the association between muscle strength and prevalence of NAFLD. We investigated the association by using relative handgrip strength in a nationwide cross-sectional survey. The participants were recruited from the Korean National Health and Nutrition Examination Surveys (KNHANES). A total of 27,531 subjects from the KNHANES were selected in our study. We used normalized handgrip strength, which is called relative handgrip strength. The index was defined as handgrip strength divided by BMI. These subjects were divided into quartile groups according to relative handgrip strength. NAFLD was defined as hepatic steatosis index >36. Multinomial logistic regression was analysed to investigate the association between relative handgrip strength with prevalence of NAFLD. The mean age of study population was 45.8 ± 0.3 in men, and 48.3 ± 0.2 in women. The proportion of males was 37.5%. In multiple linear regression, relative handgrip strength was inversely associated with HSI index (Standardized β = -0.70; standard error (SE), 0.08; p < 0.001 in men, Standardized β = -0.94; standard error (SE), 0.07; p < 0.001 in women). According to the logistic regression model, the prevalence of NAFLD decreased with quartile 4 groups in relative handgrip strength, compared with quartile 1 groups (OR 0.42 [0.32-0.55] in men; OR 0.30 [0.22-0.40] in women). Relative handgrip strength, used as a biomarker of sarcopenia, is independently inversely associated with NAFLD.
Files in This Item:
T202200393.pdf Download
DOI
10.3390/ijerph19031675
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Yu-Jin(권유진) ORCID logo https://orcid.org/0000-0002-9021-3856
Jung, Dong Hyuk(정동혁) ORCID logo https://orcid.org/0000-0002-3411-0676
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187989
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