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Antioxidant-Rich Dietary Intervention Improves Cardiometabolic Profiles and Arterial Stiffness in Elderly Koreans with Metabolic Syndrome

 Hye-Kyung Chung  ;  Jung Hye Kim  ;  Arim Choi  ;  Chul Woo Ahn  ;  Yu-Sik Kim  ;  Ji Sun Nam 
 YONSEI MEDICAL JOURNAL, Vol.63(1) : 26-33, 2022-01 
Journal Title
Issue Date
Aged ; Ankle Brachial Index ; Antioxidants ; Blood Pressure ; Humans ; Hypertension* ; Metabolic Syndrome* ; Pulse Wave Analysis ; Republic of Korea ; Vascular Stiffness*
Diet therapy ; metabolic syndrome ; oxidative stress ; vascular stiffness
Purpose: Oxidative stress plays an important role in the pathogenesis of chronic metabolic diseases. This study investigated the effect of the antioxidant-rich dietary intervention on oxidative stress, metabolic parameters, and arterial stiffness in elderly Koreans with metabolic syndrome (MetS).

Materials and methods: Thirty-one subjects with MetS were enrolled and randomly divided into dietary intervention group and control group. Subjects in the intervention group received three meal boxes prepared with antioxidant-rich ingredients every day for 4 weeks, and subjects in the control group maintained their usual diets. Anthropometric and various biochemical parameters related to oxidative stress, inflammation, and MetS were assessed. Brachial-ankle pulse wave velocity (baPWV) and fat measurement using computed tomography were also conducted before and after 4 weeks.

Results: There were significant differences in waist circumference, visceral to subcutaneous fat ratio, lipid peroxidation, oxidized low density lipoprotein (oxLDL), systolic and diastolic blood pressure, lipid parameters, advanced glycation end products, and baPWV between before and after the study in the experimental group (all p<0.05). Significant inter-group differences were observed between the experimental and control group in terms of the differences in body mass index, waist circumference, oxygen radical absorbance capacity, protein carboxylation, lipid peroxidation, oxLDL, blood pressure, lipid parameters, and baPWV between before and after the study (all p<0.05).

Conclusion: Antioxidant-rich dietary intervention for a 4-week period ameliorated the state of oxidative stress and improved the components of MetS including central obesity, dyslipidemia, hypertension, and arterial stiffness in elderly Koreans with MetS.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yu-Sik(김유식)
Kim, Jung Hye(김정혜)
Nam, Ji Sun(남지선) ORCID logo https://orcid.org/0000-0001-8655-5258
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Chung, Hye Kyung(정혜경)
Choi, Arim(최아림)
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