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Evaluation of the skin phototoxicity of systemically administered pharmaceuticals in Sprague-Dawley rats

Authors
 Eun Ji Kim  ;  Nam Hee Youn  ;  Jung-Sun Yi  ;  Joo Hwan Kim  ;  Ye-Jin Cho  ;  Ki Taek Nam  ;  Ki Sook Park  ;  Jong Kwon Lee 
Citation
 TOXICOLOGICAL RESEARCH, Vol.37(4) : 435-442, 44228 
Journal Title
TOXICOLOGICAL RESEARCH
ISSN
 1976-8257 
Issue Date
4422-08
Keywords
Histopathological finding ; In vivo test ; Phototoxicity ; Skin reaction ; UVA
Abstract
In vivo phototoxicity testing is important for predicting drug-induced phototoxicity in humans. Currently, there is no internationally validated in vivo test method for the photosafety evaluation of pharmaceuticals. In this study, we evaluated the phototoxicity of systemically administered drugs using SD rats. We first determined the appropriate ultraviolet A (UVA) dose using 8-methoxypsoralen, a well-known phototoxic drug. Compared to lower and higher UVA doses, we found that a UVA dose of 10 J/cm2 allowed for the detection of phototoxic responses in both a dose- and time-dependent manner. We next performed a phototoxicity study using seven pharmaceutical drugs which included known phototoxic and non-phototoxic drugs using a UVA dose of 10 J/cm2. In order to improve the accuracy of our assessment, we evaluated both gross skin findings as well as histopathological findings. Using gross skin findings alone resulted in an accuracy of 85.7% which could be increased to 100% accuracy when the gross skin findings were combined with histopathological findings. This study suggests that the inclusion of histopathological findings increases the accuracy of the phototoxicity evaluation of systemically administered drugs in SD rats. In conclusion, we found that for studying drug-induced phytotoxicity, a 10 J/cm2 UVA dose serves as the optimal radiation dose, and that the inclusion of histopathological findings increases the accuracy of the phototoxicity evaluation of the drugs.
Full Text
https://link.springer.com/article/10.1007/s43188-020-00078-7
DOI
10.1007/s43188-020-00078-7
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Nam, Ki Taek(남기택)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187804
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