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Evaluation of the skin phototoxicity of systemically administered pharmaceuticals in Sprague-Dawley rats

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dc.contributor.author남기택-
dc.contributor.author남기택-
dc.contributor.author남기택-
dc.date.accessioned2022-03-11T05:48:38Z-
dc.date.available2022-03-11T05:48:38Z-
dc.date.issued44228-
dc.identifier.issn1976-8257-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187804-
dc.description.abstractIn vivo phototoxicity testing is important for predicting drug-induced phototoxicity in humans. Currently, there is no internationally validated in vivo test method for the photosafety evaluation of pharmaceuticals. In this study, we evaluated the phototoxicity of systemically administered drugs using SD rats. We first determined the appropriate ultraviolet A (UVA) dose using 8-methoxypsoralen, a well-known phototoxic drug. Compared to lower and higher UVA doses, we found that a UVA dose of 10 J/cm2 allowed for the detection of phototoxic responses in both a dose- and time-dependent manner. We next performed a phototoxicity study using seven pharmaceutical drugs which included known phototoxic and non-phototoxic drugs using a UVA dose of 10 J/cm2. In order to improve the accuracy of our assessment, we evaluated both gross skin findings as well as histopathological findings. Using gross skin findings alone resulted in an accuracy of 85.7% which could be increased to 100% accuracy when the gross skin findings were combined with histopathological findings. This study suggests that the inclusion of histopathological findings increases the accuracy of the phototoxicity evaluation of systemically administered drugs in SD rats. In conclusion, we found that for studying drug-induced phytotoxicity, a 10 J/cm2 UVA dose serves as the optimal radiation dose, and that the inclusion of histopathological findings increases the accuracy of the phototoxicity evaluation of the drugs.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherKorean Society of Toxicology-
dc.relation.isPartOfTOXICOLOGICAL RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEvaluation of the skin phototoxicity of systemically administered pharmaceuticals in Sprague-Dawley rats-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentBioMedical Science Institute (의생명과학부)-
dc.contributor.googleauthorEun Ji Kim-
dc.contributor.googleauthorNam Hee Youn-
dc.contributor.googleauthorJung-Sun Yi-
dc.contributor.googleauthorJoo Hwan Kim-
dc.contributor.googleauthorYe-Jin Cho-
dc.contributor.googleauthorKi Taek Nam-
dc.contributor.googleauthorKi Sook Park-
dc.contributor.googleauthorJong Kwon Lee-
dc.identifier.doi10.1007/s43188-020-00078-7-
dc.contributor.localIdA01243-
dc.contributor.localIdA01243-
dc.contributor.localIdA01243-
dc.relation.journalcodeJ03278-
dc.identifier.eissn2234-2753-
dc.identifier.pmid34631500-
dc.identifier.urlhttps://link.springer.com/article/10.1007/s43188-020-00078-7-
dc.subject.keywordHistopathological finding-
dc.subject.keywordIn vivo test-
dc.subject.keywordPhototoxicity-
dc.subject.keywordSkin reaction-
dc.subject.keywordUVA-
dc.contributor.alternativeNameNam, Ki Taek-
dc.contributor.affiliatedAuthor남기택-
dc.contributor.affiliatedAuthor남기택-
dc.contributor.affiliatedAuthor남기택-
dc.citation.volume37-
dc.citation.number4-
dc.citation.startPage435-
dc.citation.endPage442-
dc.identifier.bibliographicCitationTOXICOLOGICAL RESEARCH, Vol.37(4) : 435-442, 44228-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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