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IL-15 enhances CCR5-mediated migration of memory CD8 + T cells by upregulating CCR5 expression in the absence of TCR stimulation

 In-Ho Seo  ;  Hyuk Soo Eun  ;  Ja Kyung Kim  ;  Hoyoung Lee  ;  Seongju Jeong  ;  Seong Jin Choi  ;  Jeewon Lee  ;  Byung Seok Lee  ;  Seok Hyun Kim  ;  Woo Sun Rou  ;  Dong Hyeon Lee  ;  Won Kim  ;  Su-Hyung Park  ;  Eui-Cheol Shin 
 CELL REPORTS, Vol.36(4) : 109438, 2021-07 
Journal Title
Issue Date
Acute Disease ; Adult ; Animals ; CD8-Positive T-Lymphocytes / metabolism* ; Cell Death / genetics ; Cell Movement* ; Cell Proliferation / genetics ; Female ; Hepatitis A / complications ; Hepatitis A / genetics ; Hepatitis A / immunology ; Humans ; Immunologic Memory* ; Inflammation / complications ; Inflammation / immunology ; Inflammation / pathology ; Interleukin-15 / metabolism* ; MAP Kinase Signaling System ; Male ; Mice, Inbred C57BL ; Middle Aged ; Receptors, Antigen, T-Cell / metabolism* ; Receptors, CCR5 / genetics* ; Receptors, CCR5 / metabolism ; Receptors, CCR7 / metabolism ; Up-Regulation / genetics ; Young Adult
CCR5 ; IL-15 ; bystander-activated CD8(+) T cells ; migration
During microbial infection, bystander CD8+ T cells that are not specific to infecting pathogens can be activated by interleukin (IL)-15. However, the tissue-homing properties of bystander-activated CD8+ T cells have not been elucidated. Here, we examine the effects of IL-15 on the expression of chemokine receptors on CD8+ T cells and their migration. IL-15 upregulates CCR5 in memory CD8+ T cells in the absence of T cell receptor (TCR) stimulation and enhances CCR5-dependent migration. IL-15-induced CCR5 upregulation is abrogated by TCR stimulation, indicating that CCR5 is upregulated in bystander-activated CD8+ T cells. Moreover, CCR5 signals increase proliferation and cytotoxic protein expression in IL-15-treated memory CD8+ T cells, although the increase has a small extent. CCR5 upregulation in bystander-activated CD8+ T cells is associated with severe liver injury in patients with acute hepatitis A. Altogether, the results indicate that CCR5 upregulation by IL-15 mediates the migration of bystander-activated CD8+ T cells.
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1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ja Kyung(김자경) ORCID logo https://orcid.org/0000-0001-5025-6846
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