Cited 10 times in
IL-15 enhances CCR5-mediated migration of memory CD8 + T cells by upregulating CCR5 expression in the absence of TCR stimulation
DC Field | Value | Language |
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dc.contributor.author | 김자경 | - |
dc.date.accessioned | 2022-02-23T01:30:17Z | - |
dc.date.available | 2022-02-23T01:30:17Z | - |
dc.date.issued | 2021-07 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187740 | - |
dc.description.abstract | During microbial infection, bystander CD8+ T cells that are not specific to infecting pathogens can be activated by interleukin (IL)-15. However, the tissue-homing properties of bystander-activated CD8+ T cells have not been elucidated. Here, we examine the effects of IL-15 on the expression of chemokine receptors on CD8+ T cells and their migration. IL-15 upregulates CCR5 in memory CD8+ T cells in the absence of T cell receptor (TCR) stimulation and enhances CCR5-dependent migration. IL-15-induced CCR5 upregulation is abrogated by TCR stimulation, indicating that CCR5 is upregulated in bystander-activated CD8+ T cells. Moreover, CCR5 signals increase proliferation and cytotoxic protein expression in IL-15-treated memory CD8+ T cells, although the increase has a small extent. CCR5 upregulation in bystander-activated CD8+ T cells is associated with severe liver injury in patients with acute hepatitis A. Altogether, the results indicate that CCR5 upregulation by IL-15 mediates the migration of bystander-activated CD8+ T cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Cell Press | - |
dc.relation.isPartOf | CELL REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Acute Disease | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | CD8-Positive T-Lymphocytes / metabolism* | - |
dc.subject.MESH | Cell Death / genetics | - |
dc.subject.MESH | Cell Movement* | - |
dc.subject.MESH | Cell Proliferation / genetics | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hepatitis A / complications | - |
dc.subject.MESH | Hepatitis A / genetics | - |
dc.subject.MESH | Hepatitis A / immunology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunologic Memory* | - |
dc.subject.MESH | Inflammation / complications | - |
dc.subject.MESH | Inflammation / immunology | - |
dc.subject.MESH | Inflammation / pathology | - |
dc.subject.MESH | Interleukin-15 / metabolism* | - |
dc.subject.MESH | MAP Kinase Signaling System | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Receptors, Antigen, T-Cell / metabolism* | - |
dc.subject.MESH | Receptors, CCR5 / genetics* | - |
dc.subject.MESH | Receptors, CCR5 / metabolism | - |
dc.subject.MESH | Receptors, CCR7 / metabolism | - |
dc.subject.MESH | Up-Regulation / genetics | - |
dc.subject.MESH | Young Adult | - |
dc.title | IL-15 enhances CCR5-mediated migration of memory CD8 + T cells by upregulating CCR5 expression in the absence of TCR stimulation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | In-Ho Seo | - |
dc.contributor.googleauthor | Hyuk Soo Eun | - |
dc.contributor.googleauthor | Ja Kyung Kim | - |
dc.contributor.googleauthor | Hoyoung Lee | - |
dc.contributor.googleauthor | Seongju Jeong | - |
dc.contributor.googleauthor | Seong Jin Choi | - |
dc.contributor.googleauthor | Jeewon Lee | - |
dc.contributor.googleauthor | Byung Seok Lee | - |
dc.contributor.googleauthor | Seok Hyun Kim | - |
dc.contributor.googleauthor | Woo Sun Rou | - |
dc.contributor.googleauthor | Dong Hyeon Lee | - |
dc.contributor.googleauthor | Won Kim | - |
dc.contributor.googleauthor | Su-Hyung Park | - |
dc.contributor.googleauthor | Eui-Cheol Shin | - |
dc.identifier.doi | 10.1016/j.celrep.2021.109438 | - |
dc.contributor.localId | A00852 | - |
dc.contributor.localId | A02137 | - |
dc.relation.journalcode | J00488 | - |
dc.identifier.eissn | 2211-1247 | - |
dc.identifier.pmid | 34320338 | - |
dc.subject.keyword | CCR5 | - |
dc.subject.keyword | IL-15 | - |
dc.subject.keyword | bystander-activated CD8(+) T cells | - |
dc.subject.keyword | migration | - |
dc.contributor.alternativeName | Kim, Ja Kyung | - |
dc.contributor.affiliatedAuthor | 김자경 | - |
dc.citation.volume | 36 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 109438 | - |
dc.identifier.bibliographicCitation | CELL REPORTS, Vol.36(4) : 109438, 2021-07 | - |
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