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Current laboratory tests for diagnosis of hepatitis B virus infection

Authors
 Jong-Han Lee  ;  Hyon-Suk Kim 
Citation
 INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, Vol.75(12) : e14812, 2021-12 
Journal Title
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
ISSN
 1368-5031 
Issue Date
2021-12
MeSH
DNA, Viral ; Hepatitis B Core Antigens ; Hepatitis B virus* / genetics ; Hepatitis B* / diagnosis ; Humans ; Laboratories
Abstract
Background: Hepatitis B virus (HBV) has a long history in human infectious diseases. HBV infection can progress chronically, leading to cancer. After introduction of a vaccine, the overall incidence rate of HBV infection has decreased, although it remains a health problem in many countries.

Purpose: The aim of this review was to summarise current diagnostic efforts for HBV infection and future HBV diagnosis perspectives.

Methods: We reviewed and summarised current laboratory diagnosis related with HBV infection in clinical practice.

Results: There have been various serologic- and molecular-based methods to diagnose acute or chronic HBV infection. Since intrahepatic covalently closed circular DNAs (cccDNAs) function as robust HBV replication templates, cure of chronic HBV infection is limited. Recently, new biomarkers such as hepatitis B virus core-related antigen (HBcrAg) and HBV RNA have emerged that appear to reflect intrahepatic cccDNA status. These new biomarkers should be validated before clinical usage.

Conclusion: An effective diagnostic approach and current updated knowledge of treatment response monitoring are important for HBV infection management. Brand new ultrasensitive and accurate immunologic methods may pave the way to manage HBV infection in parallel with immunotherapy era.
Full Text
https://onlinelibrary.wiley.com/doi/10.1111/ijcp.14812
DOI
10.1111/ijcp.14812
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187679
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