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Metabolic tumour volume on 18 F-FDG PET/CT predicts extended pathological T stages in patients with renal cell carcinoma at staging

Authors
 Dongwoo Kim  ;  Narae Lee  ;  Suk Hyun Lee  ;  Hyun Jeong Kim  ;  Hye-Suk Hong  ;  Jee Soo Park  ;  Nam-Hoon Cho  ;  Young Deuk Choi  ;  Won Sik Ham  ;  Seung Hwan Lee  ;  Woong Kyu Han  ;  Mijin Yun 
Citation
 SCIENTIFIC REPORTS, Vol.11(1) : 23486, 2021-12 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2021-12
MeSH
Carcinoma, Renal Cell / pathology* ; Female ; Fluorodeoxyglucose F18 / administration & dosage* ; Glycolysis / physiology ; Humans ; Kidney Neoplasms / pathology* ; Male ; Middle Aged ; Multimodal Imaging / methods ; Neoplasm Staging / methods ; Nephrectomy / methods ; Positron Emission Tomography Computed Tomography / methods ; Positron-Emission Tomography / methods ; Prognosis ; Prospective Studies ; Tomography, X-Ray Computed / methods ; Tumor Burden / physiology*
Abstract
We evaluated the predictive value of 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography/CT (PET/CT) for extended pathological T (pT) stages (≥ pT3a) in Renal cell carcinoma (RCC) patients at staging. Thirty-eight RCC patients who underwent 18F-FDG PET/CT at staging, followed by radical nephrectomy between September 2016 and September 2018, were included in this prospective study. Patients were classified into two groups (limited pT stage: stage T1/2, n = 17; extended pT stage: T3/4, n = 21). Univariate and multivariate logistic regression analyses were performed to identify clinicopathological and metabolic variables to predict extended pT stages. 18F-FDG metabolic parameters were compared in relation to International Society of Urological Pathology (ISUP) grade and lymphovascular invasion (LVI). In univariate analysis, maximum standardised uptake value, metabolic tumour volume (MTV), and ISUP grade were significant. In multivariate analysis, MTV was the only significant factor of extended pT stages. With a cut-off MTV of 21.2, an area under the curve was 0.944, which was higher than 0.824 for clinical T stages (p = 0.037). In addition, high MTV, but not tumour size, was significantly correlated with aggressive pathologic features (ISUP grade and LVI). High glycolytic tumour volume on 18F-FDG PET/CT in RCC patients at staging is predictive of extended pT stages which could aid decision-making regarding the best type of surgery
Files in This Item:
T202125041.pdf Download
DOI
10.1038/s41598-021-03023-2
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dongwoo(김동우) ORCID logo https://orcid.org/0000-0002-1723-604X
Kim, Hyun Jeong(김현정) ORCID logo https://orcid.org/0000-0002-3116-8848
Park, Jee Soo(박지수) ORCID logo https://orcid.org/0000-0001-9976-6599
Yun, Mi Jin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
Lee, Seung Hwan(이승환) ORCID logo https://orcid.org/0000-0001-7358-8544
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
Han, Woong Kyu(한웅규) ORCID logo https://orcid.org/0000-0002-2527-4046
Ham, Won Sik(함원식) ORCID logo https://orcid.org/0000-0003-2246-8838
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187667
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