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Effect of Dexamethasone Combination with Gentamicin in Chemical Labyrinthectomy on Hearing Preservation and Vertigo Control in Patients with Unilateral Meniere's Disease: A Randomized Controlled Clinical Trial

Authors
 Seong-Hoon Bae  ;  Jeon-Mi Lee  ;  Hyun-Jin Lee  ;  Gina Na  ;  Sung-Huhn Kim 
Citation
 JOURNAL OF CLINICAL MEDICINE, Vol.10(23) : 5581, 2021-11 
Journal Title
JOURNAL OF CLINICAL MEDICINE
Issue Date
2021-11
Keywords
Meniere’s disease ; chemical labyrinthectomy ; dexamethasone ; gentamicin
Abstract
Chemical labyrinthectomy using gentamicin is a popular method for treating intractable vertigo attacks in Meniere's disease. However, the risk of hearing loss remains a major concern for clinicians. We investigated the effect of simultaneous dexamethasone and gentamicin application on hearing preservation and vertigo control in patients with intractable unilateral Meniere's disease. A single-institutional, prospective, single-blinded, randomized clinical trial was conducted. Gentamicin-soaked Gelfoam® was directly applied on the oval window following middle ear exploration. On the round window, dexamethasone-soaked Gelfoam® was applied in the gentamicin with dexamethasone group (GD group, n = 18), and saline-soaked Gelfoam® was applied in the gentamicin with sham reagent group (GO group, n = 19). The hearing change 8 weeks after the procedure and vertigo control 2-12 months after the procedure were investigated. The high-frequency hearing threshold was significantly increased in the GO group (p = 0.005 and 0.012 for 4 and 8 kHz, respectively), but not in the GD group. The short-term (2-6 months) vertigo control was more successful in the GD group (57.89% vs. 94.44%, p = 0.019), but long-term control (6-12 months) was insignificant. In conclusion, the combined application of gentamicin and dexamethasone in chemical labyrinthectomy is an effective method for protecting high-frequency hearing and vertigo control.
Files in This Item:
T202125004.pdf Download
DOI
10.3390/jcm10235581
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Huhn(김성헌)
Bae, Seong Hoon(배성훈) ORCID logo https://orcid.org/0000-0001-9243-9392
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187645
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