Cited 6 times in
Effect of Dexamethasone Combination with Gentamicin in Chemical Labyrinthectomy on Hearing Preservation and Vertigo Control in Patients with Unilateral Meniere's Disease: A Randomized Controlled Clinical Trial
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김성헌 | - |
dc.contributor.author | 배성훈 | - |
dc.date.accessioned | 2022-02-23T01:20:38Z | - |
dc.date.available | 2022-02-23T01:20:38Z | - |
dc.date.issued | 2021-11 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187645 | - |
dc.description.abstract | Chemical labyrinthectomy using gentamicin is a popular method for treating intractable vertigo attacks in Meniere's disease. However, the risk of hearing loss remains a major concern for clinicians. We investigated the effect of simultaneous dexamethasone and gentamicin application on hearing preservation and vertigo control in patients with intractable unilateral Meniere's disease. A single-institutional, prospective, single-blinded, randomized clinical trial was conducted. Gentamicin-soaked Gelfoam® was directly applied on the oval window following middle ear exploration. On the round window, dexamethasone-soaked Gelfoam® was applied in the gentamicin with dexamethasone group (GD group, n = 18), and saline-soaked Gelfoam® was applied in the gentamicin with sham reagent group (GO group, n = 19). The hearing change 8 weeks after the procedure and vertigo control 2-12 months after the procedure were investigated. The high-frequency hearing threshold was significantly increased in the GO group (p = 0.005 and 0.012 for 4 and 8 kHz, respectively), but not in the GD group. The short-term (2-6 months) vertigo control was more successful in the GD group (57.89% vs. 94.44%, p = 0.019), but long-term control (6-12 months) was insignificant. In conclusion, the combined application of gentamicin and dexamethasone in chemical labyrinthectomy is an effective method for protecting high-frequency hearing and vertigo control. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Effect of Dexamethasone Combination with Gentamicin in Chemical Labyrinthectomy on Hearing Preservation and Vertigo Control in Patients with Unilateral Meniere's Disease: A Randomized Controlled Clinical Trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학교실) | - |
dc.contributor.googleauthor | Seong-Hoon Bae | - |
dc.contributor.googleauthor | Jeon-Mi Lee | - |
dc.contributor.googleauthor | Hyun-Jin Lee | - |
dc.contributor.googleauthor | Gina Na | - |
dc.contributor.googleauthor | Sung-Huhn Kim | - |
dc.identifier.doi | 10.3390/jcm10235581 | - |
dc.contributor.localId | A00589 | - |
dc.contributor.localId | A05563 | - |
dc.relation.journalcode | J03556 | - |
dc.identifier.eissn | 2077-0383 | - |
dc.identifier.pmid | 34884281 | - |
dc.subject.keyword | Meniere’s disease | - |
dc.subject.keyword | chemical labyrinthectomy | - |
dc.subject.keyword | dexamethasone | - |
dc.subject.keyword | gentamicin | - |
dc.contributor.alternativeName | Kim, Sung Huhn | - |
dc.contributor.affiliatedAuthor | 김성헌 | - |
dc.contributor.affiliatedAuthor | 배성훈 | - |
dc.citation.volume | 10 | - |
dc.citation.number | 23 | - |
dc.citation.startPage | 5581 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, Vol.10(23) : 5581, 2021-11 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.