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Method Categorization of Stem Cell Therapy for Degenerative Osteoarthritis of the Knee: A Review

Authors
 Jae Sun Lee  ;  Dong Woo Shim  ;  Kyung-Yil Kang  ;  Dong-Sik Chae  ;  Woo-Suk Lee 
Citation
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.22(24) : 13323, 2021-12 
Journal Title
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Issue Date
2021-12
MeSH
Cartilage, Articular* / metabolism ; Cartilage, Articular* / pathology ; Humans ; Knee Joint / metabolism ; Knee Joint / pathology ; Mesenchymal Stem Cell Transplantation* ; Mesenchymal Stem Cells* / metabolism ; Mesenchymal Stem Cells* / pathology ; Osteoarthritis, Knee* / metabolism ; Osteoarthritis, Knee* / pathology ; Osteoarthritis, Knee* / therapy
Keywords
cartilage regeneration ; degenerative osteoarthritis ; knee ; stem cell therapy
Abstract
Current clinical applications of mesenchymal stem cell therapy for osteoarthritis lack consistency because there are no established criteria for clinical processes. We aimed to systematically organize stem cell treatment methods by reviewing the literature. The treatment methods used in 27 clinical trials were examined and reviewed. The clinical processes were separated into seven categories: cell donor, cell source, cell preparation, delivery methods, lesion preparation, concomitant procedures, and evaluation. Stem cell donors were sub-classified as autologous and allogeneic, and stem cell sources included bone marrow, adipose tissue, peripheral blood, synovium, placenta, and umbilical cord. Mesenchymal stem cells can be prepared by the expansion or isolation process and attached directly to cartilage defects using matrices or injected into joints under arthroscopic observation. The lesion preparation category can be divided into three subcategories: chondroplasty, microfracture, and subchondral drilling. The concomitant procedure category describes adjuvant surgery, such as high tibial osteotomy. Classification codes were assigned for each subcategory to provide a useful and convenient method for organizing documents associated with stem cell treatment. This classification system will help researchers choose more unified treatment methods, which will facilitate the efficient comparison and verification of future clinical outcomes of stem cell therapy for osteoarthritis.
Files in This Item:
T202124988.pdf Download
DOI
10.3390/ijms222413323
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Woo Suk(이우석) ORCID logo https://orcid.org/0000-0002-0798-1660
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187629
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