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Method Categorization of Stem Cell Therapy for Degenerative Osteoarthritis of the Knee: A Review

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dc.contributor.author이우석-
dc.date.accessioned2022-02-23T01:18:50Z-
dc.date.available2022-02-23T01:18:50Z-
dc.date.issued2021-12-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187629-
dc.description.abstractCurrent clinical applications of mesenchymal stem cell therapy for osteoarthritis lack consistency because there are no established criteria for clinical processes. We aimed to systematically organize stem cell treatment methods by reviewing the literature. The treatment methods used in 27 clinical trials were examined and reviewed. The clinical processes were separated into seven categories: cell donor, cell source, cell preparation, delivery methods, lesion preparation, concomitant procedures, and evaluation. Stem cell donors were sub-classified as autologous and allogeneic, and stem cell sources included bone marrow, adipose tissue, peripheral blood, synovium, placenta, and umbilical cord. Mesenchymal stem cells can be prepared by the expansion or isolation process and attached directly to cartilage defects using matrices or injected into joints under arthroscopic observation. The lesion preparation category can be divided into three subcategories: chondroplasty, microfracture, and subchondral drilling. The concomitant procedure category describes adjuvant surgery, such as high tibial osteotomy. Classification codes were assigned for each subcategory to provide a useful and convenient method for organizing documents associated with stem cell treatment. This classification system will help researchers choose more unified treatment methods, which will facilitate the efficient comparison and verification of future clinical outcomes of stem cell therapy for osteoarthritis.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHCartilage, Articular* / metabolism-
dc.subject.MESHCartilage, Articular* / pathology-
dc.subject.MESHHumans-
dc.subject.MESHKnee Joint / metabolism-
dc.subject.MESHKnee Joint / pathology-
dc.subject.MESHMesenchymal Stem Cell Transplantation*-
dc.subject.MESHMesenchymal Stem Cells* / metabolism-
dc.subject.MESHMesenchymal Stem Cells* / pathology-
dc.subject.MESHOsteoarthritis, Knee* / metabolism-
dc.subject.MESHOsteoarthritis, Knee* / pathology-
dc.subject.MESHOsteoarthritis, Knee* / therapy-
dc.titleMethod Categorization of Stem Cell Therapy for Degenerative Osteoarthritis of the Knee: A Review-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Orthopedic Surgery (정형외과학교실)-
dc.contributor.googleauthorJae Sun Lee-
dc.contributor.googleauthorDong Woo Shim-
dc.contributor.googleauthorKyung-Yil Kang-
dc.contributor.googleauthorDong-Sik Chae-
dc.contributor.googleauthorWoo-Suk Lee-
dc.identifier.doi10.3390/ijms222413323-
dc.contributor.localIdA02992-
dc.relation.journalcodeJ01133-
dc.identifier.eissn1422-0067-
dc.identifier.pmid34948119-
dc.subject.keywordcartilage regeneration-
dc.subject.keyworddegenerative osteoarthritis-
dc.subject.keywordknee-
dc.subject.keywordstem cell therapy-
dc.contributor.alternativeNameLee, Woo Suk-
dc.contributor.affiliatedAuthor이우석-
dc.citation.volume22-
dc.citation.number24-
dc.citation.startPage13323-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.22(24) : 13323, 2021-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers

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