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Treatment outcomes of neoadjuvant chemotherapy and transoral robotic surgery in locoregionally advanced laryngopharyngeal carcinoma

Authors
 Lorenzo S Solimeno  ;  Young Min Park  ;  Jae-Yol Lim  ;  Yoon Woo Koh  ;  Se-Heon Kim 
Citation
 HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, Vol.43(11) : 3429-3436, 2021-11 
Journal Title
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
ISSN
 1043-3074 
Issue Date
2021-11
MeSH
Head and Neck Neoplasms* ; Humans ; Hypopharyngeal Neoplasms* ; Neoadjuvant Therapy ; Robotic Surgical Procedures* ; Treatment Outcome
Keywords
adverse pathologic features ; head and neck squamous cell carcinoma ; neoadjuvant chemotherapy ; radiotherapy ; transoral robotic surgery
Abstract
Background: We aimed to identify the optimal indications of neoadjuvant chemotherapy (NACT) and transoral robotic surgery (TORS) in patients with locoregionally advanced (T3-4 or N2-3) head and neck cancer (HNC).

Methods: A total of 50 patients were included in the study.

Results: T1 was identified in seven cases, T2 in 19, T3 in 22, and T4 in 2. N0 was identified in nine cases, N1 in 18, N2 in 22, and N3 in 1. There were 25 patients (50%) with complete remission of the primary lesion and 25 patients (50%) with partial remission. On pathologic examination of surgical specimens after neoadjuvant chemotherapy and TORS, 2 patients (4%) had a positive surgical margin, and 48 patients (96%) had a negative margin. Pathologic metastatic lymph nodes (LNs) were not observed in 39 cases (78%), and one metastatic LN was observed in 11 cases (22%). The 3-year recurrence-free survival (RFS) of all patients was 85.4%. On multivariate analysis, lymphovascular invasion showed a significant correlation with RFS.

Conclusions: In patients with locoregionally advanced HNC, NACT and TORS achieved favorable oncologic and functional outcomes.
Full Text
https://onlinelibrary.wiley.com/doi/10.1002/hed.26838
DOI
10.1002/hed.26838
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Koh, Yoon Woo(고윤우)
Kim, Se Heon(김세헌)
Park, Young Min(박영민) ORCID logo https://orcid.org/0000-0002-7593-8461
Lim, Jae Yol(임재열) ORCID logo https://orcid.org/0000-0002-9757-6414
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187595
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