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Treatment outcomes of neoadjuvant chemotherapy and transoral robotic surgery in locoregionally advanced laryngopharyngeal carcinoma

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dc.contributor.author고윤우-
dc.contributor.author김세헌-
dc.contributor.author박영민-
dc.contributor.author임재열-
dc.date.accessioned2022-02-23T01:14:14Z-
dc.date.available2022-02-23T01:14:14Z-
dc.date.issued2021-11-
dc.identifier.issn1043-3074-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187595-
dc.description.abstractBackground: We aimed to identify the optimal indications of neoadjuvant chemotherapy (NACT) and transoral robotic surgery (TORS) in patients with locoregionally advanced (T3-4 or N2-3) head and neck cancer (HNC). Methods: A total of 50 patients were included in the study. Results: T1 was identified in seven cases, T2 in 19, T3 in 22, and T4 in 2. N0 was identified in nine cases, N1 in 18, N2 in 22, and N3 in 1. There were 25 patients (50%) with complete remission of the primary lesion and 25 patients (50%) with partial remission. On pathologic examination of surgical specimens after neoadjuvant chemotherapy and TORS, 2 patients (4%) had a positive surgical margin, and 48 patients (96%) had a negative margin. Pathologic metastatic lymph nodes (LNs) were not observed in 39 cases (78%), and one metastatic LN was observed in 11 cases (22%). The 3-year recurrence-free survival (RFS) of all patients was 85.4%. On multivariate analysis, lymphovascular invasion showed a significant correlation with RFS. Conclusions: In patients with locoregionally advanced HNC, NACT and TORS achieved favorable oncologic and functional outcomes.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherJohn Wiley And Sons-
dc.relation.isPartOfHEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHHead and Neck Neoplasms*-
dc.subject.MESHHumans-
dc.subject.MESHHypopharyngeal Neoplasms*-
dc.subject.MESHNeoadjuvant Therapy-
dc.subject.MESHRobotic Surgical Procedures*-
dc.subject.MESHTreatment Outcome-
dc.titleTreatment outcomes of neoadjuvant chemotherapy and transoral robotic surgery in locoregionally advanced laryngopharyngeal carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Otorhinolaryngology (이비인후과학교실)-
dc.contributor.googleauthorLorenzo S Solimeno-
dc.contributor.googleauthorYoung Min Park-
dc.contributor.googleauthorJae-Yol Lim-
dc.contributor.googleauthorYoon Woo Koh-
dc.contributor.googleauthorSe-Heon Kim-
dc.identifier.doi10.1002/hed.26838-
dc.contributor.localIdA00133-
dc.contributor.localIdA00605-
dc.contributor.localIdA01566-
dc.contributor.localIdA03396-
dc.relation.journalcodeJ00963-
dc.identifier.eissn1097-0347-
dc.identifier.pmid34355819-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1002/hed.26838-
dc.subject.keywordadverse pathologic features-
dc.subject.keywordhead and neck squamous cell carcinoma-
dc.subject.keywordneoadjuvant chemotherapy-
dc.subject.keywordradiotherapy-
dc.subject.keywordtransoral robotic surgery-
dc.contributor.alternativeNameKoh, Yoon Woo-
dc.contributor.affiliatedAuthor고윤우-
dc.contributor.affiliatedAuthor김세헌-
dc.contributor.affiliatedAuthor박영민-
dc.contributor.affiliatedAuthor임재열-
dc.citation.volume43-
dc.citation.number11-
dc.citation.startPage3429-
dc.citation.endPage3436-
dc.identifier.bibliographicCitationHEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, Vol.43(11) : 3429-3436, 2021-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

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