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Diffusion tensor imaging-based pontine damage as a degeneration marker in synucleinopathy

Authors
 Seok Jong Chung  ;  Kyoo Ho Cho  ;  Yang Hyun Lee  ;  Han Soo Yoo  ;  KyoungWon Baik  ;  Jin Ho Jung  ;  Byoung Seok Ye  ;  Young H Sohn  ;  Jungho Cha  ;  Phil Hyu Lee 
Citation
 JOURNAL OF NEUROSCIENCE RESEARCH, Vol.99(11) : 2922-2931, 2021-11 
Journal Title
JOURNAL OF NEUROSCIENCE RESEARCH
ISSN
 0360-4012 
Issue Date
2021-11
Keywords
diffusion tensor imaging ; mean diffusivity ; pons ; synucleinopathy
Abstract
The pons is one of the earliest affected regions in patients with synucleinopathies. We aimed to investigate the diagnostic value of measuring pontine damage using diffusion tensor imaging (DTI) in these patients. We enrolled 49 patients with Parkinson's disease (PD), 16 patients with idiopathic rapid eye movement sleep behavior disorder (iRBD), 23 patients with multiple system atrophy (MSA), and 39 healthy controls in this study. All the participants underwent high-resolution T1-weighted imaging and DTI. Mean diffusivity (MD) and fraction anisotropy (FA) values in the pons were calculated to characterize structural damage. The discriminatory power of pontine MD and FA values to differentiate patients with synucleinopathies from healthy controls was examined using receiver operating characteristics (ROC) analyses. Compared to healthy controls, patients with PD, iRBD, and MSA had increased MD values and decreased FA values in the pons, although no correlation was observed between these DTI measures and disease severity. The ROC analyses showed that MD values in the pons had a fair discriminatory power to differentiate healthy controls from patients with PD (area under the curve [AUC], 0.813), iRBD (AUC, 0.779), and MSA (AUC, 0.951). The AUC for pontine FA values was smaller than that for pontine MD values when differentiating healthy controls from patients with PD (AUC, 0.713; p = 0.054) and iRBD (AUC, 0.686; p = 0.045). Our results suggest that MD values in the pons may be a useful marker of brain stem neurodegeneration in patients with synucleinopathies.
Full Text
https://onlinelibrary.wiley.com/doi/10.1002/jnr.24926
DOI
10.1002/jnr.24926
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Baik, Kyoungwon(백경원) ORCID logo https://orcid.org/0000-0001-7215-375X
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
Yoo, Han Soo(유한수) ORCID logo https://orcid.org/0000-0001-7846-6271
Lee, Yang Hyun(이양현)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Chung, Seok Jong(정석종) ORCID logo https://orcid.org/0000-0001-6086-3199
Jung, Jin Ho(정진호)
Cho, Kyoo Ho(조규호) ORCID logo https://orcid.org/0000-0003-2402-7198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187556
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