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Neural correlates of self-awareness of cognitive deficits in non-demented patients with Parkinson's disease

Authors
 Han Soo Yoo  ;  Hyeokjin Kwon  ;  Seok Jong Chung  ;  Young H Sohn  ;  Jong-Min Lee  ;  Phil Hyu Lee 
Citation
 EUROPEAN JOURNAL OF NEUROLOGY, Vol.28(12) : 4022-4030, 2021-12 
Journal Title
EUROPEAN JOURNAL OF NEUROLOGY
ISSN
 1351-5101 
Issue Date
2021-12
Keywords
Parkinson's disease ; cognitive deficits ; frontal lobe ; self-awareness ; structural connectivity
Abstract
Background and purpose: The aim was to investigate the neural correlates of impaired self-awareness of cognitive deficits (IACd) in non-demented patients with Parkinson's disease (PD).

Methods: This cross-sectional study enrolled 153 drug-naïve and non-demented PD patients who underwent brain magnetic resonance imaging, dopamine transporter (DAT) positron emission tomography, detailed neuropsychological testing, and the Cognitive Complaints Interview at baseline. Based on the presence of mild cognitive impairment and subjective cognitive complaints, patients were grouped into those with IACd (PD-IACd+, n = 33) and those with normal recognition of cognitive function (n = 82) or underestimation of cognitive function (n = 38). Cortical thickness, white matter (WM) integrity, DAT availability and cognitive function were compared between the groups.

Results: The prevalence of IACd was 21.6% in drug-naïve patients with PD. The PD-IACd+ group had a lower z-score in the Stroop color reading test than the other groups. Patients in the PD-IACd+ group had WM disintegrity, especially in the genu of the corpus callosum and anterior limb of the internal capsule, compared to those without IACd, whilst cortical thickness or striatal DAT availability was comparable regardless of the presence of IACd. Amongst patients with mild cognitive impairment, those with IACd had more severe WM disintegrity than those without IACd.

Conclusion: Structural connectivity between and from the frontal lobes is closely associated with self-awareness of cognitive deficits in PD. Evaluating frontal structural connectivity from the early stages of PD will be important in assessing the actual cognitive and daily life performance of patients with PD.
Full Text
https://onlinelibrary.wiley.com/doi/10.1111/ene.15095
DOI
10.1111/ene.15095
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Yoo, Han Soo(유한수) ORCID logo https://orcid.org/0000-0001-7846-6271
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Chung, Seok Jong(정석종) ORCID logo https://orcid.org/0000-0001-6086-3199
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187431
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