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Association between a family history of diabetes and carotid artery atherosclerosis in Korean adults

 Sun Young Shim  ;  Ga Bin Lee  ;  Jee-Seon Shim  ;  Sun Jae Jung  ;  Hyeon Chang Kim 
 EPIDEMIOLOGY AND HEALTH, Vol.43 : e2021049, 2021 
Journal Title
Issue Date
Adult ; Atherosclerosis / epidemiology* ; Carotid Artery Diseases / epidemiology* ; Cross-Sectional Studies ; Diabetes Mellitus / epidemiology ; Diabetes Mellitus / genetics* ; Family Health / statistics & numerical data* ; Female ; Humans ; Male ; Middle Aged ; Republic of Korea / epidemiology ; Risk Assessment
Atherosclerosis ; Carotid intima-media thickness ; Diabetes mellitus ; Medical history taking
Objectives: Diabetes is a well-known risk factor for atherosclerosis, but the association between a family history of diabetes and atherosclerosis remains unknown. In this study, we assessed the association between a family history of diabetes and increased carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis, in a middle-aged Korean population.

Methods: This cross-sectional study included 3,974 community-dwelling adults (1,404 male and 2,570 female) aged 30-64 years from the Cardiovascular and Metabolic Diseases Etiology Research Center cohort. The presence of a family history of diabetes was assessed through face-to-face interviews using a standardized questionnaire. Carotid IMT was assessed using B-mode ultrasonography, and increased IMT was defined as a value in the top quartile of the IMT values of all participants. Multivariate logistic regression was used to evaluate independent associations between a family history of diabetes and increased IMT.

Results: A family history of diabetes was significantly associated with increased carotid IMT (odds ratio, 1.23; 95% confidence interval, 1.03 to 1.48) after adjusting for sex; age; body mass index; systolic blood pressure; total cholesterol, triglyceride, and hemoglobin A1c levels; smoking; alcohol consumption; exercise; use of antidiabetic, antihypertensive, and antilipidemic drugs; and a family history of hypertension. The positive association remained significant after excluding participants with diabetes (odds ratio, 1.21; 95% confidence interval, 1.00 to 1.47).

Conclusions: A family history of diabetes was positively associated with increased carotid IMT, even in participants without diabetes. Therefore, information on a family history of diabetes may help identify individuals at high risk of atherosclerotic cardiovascular disease.
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1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Shim, Jee Seon(심지선) ORCID logo https://orcid.org/0000-0002-8671-3153
Jung, Sun Jae(정선재) ORCID logo https://orcid.org/0000-0002-5194-7339
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