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Activation or exhaustion of CD8 + T cells in patients with COVID-19

Authors
 Min-Seok Rha  ;  Eui-Cheol Shin 
Citation
 CELLULAR & MOLECULAR IMMUNOLOGY, Vol.18(10) : 2325-2333, 2021-10 
Journal Title
CELLULAR & MOLECULAR IMMUNOLOGY
ISSN
 1672-7681 
Issue Date
2021-10
MeSH
CD8-Positive T-Lymphocytes / immunology* ; COVID-19 / immunology* ; COVID-19 Vaccines / immunology ; Humans ; Immunologic Memory ; Lymphocyte Activation ; Lymphocyte Count
Keywords
Activation ; CD8+ T cell ; COVID-19 ; SARS-CoV-2 ; T-cell exhaustion
Abstract
In addition to CD4+ T cells and neutralizing antibodies, CD8+ T cells contribute to protective immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID-19), an ongoing pandemic disease. In patients with COVID-19, CD8+ T cells exhibiting activated phenotypes are commonly observed, although the absolute number of CD8+ T cells is decreased. In addition, several studies have reported an upregulation of inhibitory immune checkpoint receptors, such as PD-1, and the expression of exhaustion-associated gene signatures in CD8+ T cells from patients with COVID-19. However, whether CD8+ T cells are truly exhausted during COVID-19 has been a controversial issue. In the present review, we summarize the current understanding of CD8+ T-cell exhaustion and describe the available knowledge on the phenotypes and functions of CD8+ T cells in the context of activation and exhaustion. We also summarize recent reports regarding phenotypical and functional analyses of SARS-CoV-2-specific CD8+ T cells and discuss long-term SARS-CoV-2-specific CD8+ T-cell memory.
Files in This Item:
T999202120.pdf Download
DOI
10.1038/s41423-021-00750-4
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Rha, Min-Seok(나민석) ORCID logo https://orcid.org/0000-0003-1426-7534
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187367
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