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Activation or exhaustion of CD8 + T cells in patients with COVID-19

DC Field Value Language
dc.contributor.author나민석-
dc.date.accessioned2022-01-26T00:35:46Z-
dc.date.available2022-01-26T00:35:46Z-
dc.date.issued2021-10-
dc.identifier.issn1672-7681-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187367-
dc.description.abstractIn addition to CD4+ T cells and neutralizing antibodies, CD8+ T cells contribute to protective immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID-19), an ongoing pandemic disease. In patients with COVID-19, CD8+ T cells exhibiting activated phenotypes are commonly observed, although the absolute number of CD8+ T cells is decreased. In addition, several studies have reported an upregulation of inhibitory immune checkpoint receptors, such as PD-1, and the expression of exhaustion-associated gene signatures in CD8+ T cells from patients with COVID-19. However, whether CD8+ T cells are truly exhausted during COVID-19 has been a controversial issue. In the present review, we summarize the current understanding of CD8+ T-cell exhaustion and describe the available knowledge on the phenotypes and functions of CD8+ T cells in the context of activation and exhaustion. We also summarize recent reports regarding phenotypical and functional analyses of SARS-CoV-2-specific CD8+ T cells and discuss long-term SARS-CoV-2-specific CD8+ T-cell memory.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Pub. Group-
dc.relation.isPartOfCELLULAR & MOLECULAR IMMUNOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHCD8-Positive T-Lymphocytes / immunology*-
dc.subject.MESHCOVID-19 / immunology*-
dc.subject.MESHCOVID-19 Vaccines / immunology-
dc.subject.MESHHumans-
dc.subject.MESHImmunologic Memory-
dc.subject.MESHLymphocyte Activation-
dc.subject.MESHLymphocyte Count-
dc.titleActivation or exhaustion of CD8 + T cells in patients with COVID-19-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Otorhinolaryngology (이비인후과학교실)-
dc.contributor.googleauthorMin-Seok Rha-
dc.contributor.googleauthorEui-Cheol Shin-
dc.identifier.doi10.1038/s41423-021-00750-4-
dc.contributor.localIdA06187-
dc.relation.journalcodeJ00495-
dc.identifier.eissn2042-0226-
dc.identifier.pmid34413488-
dc.subject.keywordActivation-
dc.subject.keywordCD8+ T cell-
dc.subject.keywordCOVID-19-
dc.subject.keywordSARS-CoV-2-
dc.subject.keywordT-cell exhaustion-
dc.contributor.alternativeNameRha, Min-Seok-
dc.contributor.affiliatedAuthor나민석-
dc.citation.volume18-
dc.citation.number10-
dc.citation.startPage2325-
dc.citation.endPage2333-
dc.identifier.bibliographicCitationCELLULAR & MOLECULAR IMMUNOLOGY, Vol.18(10) : 2325-2333, 2021-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

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