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Age-adjusted quick Sequential Organ Failure Assessment score for predicting mortality and disease severity in children with infection: a systematic review and meta-analysis

Authors
 Sohyun Eun  ;  Haemin Kim  ;  Ha Yan Kim  ;  Myeongjee Lee  ;  Go Eun Bae  ;  Heoungjin Kim  ;  Chung Mo Koo  ;  Moon Kyu Kim  ;  Seo Hee Yoon 
Citation
 SCIENTIFIC REPORTS, Vol.11(1) : 21699, 2021-11 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2021-11
Abstract
We assessed the diagnostic accuracy of the age-adjusted quick Sequential Organ Failure Assessment score (qSOFA) for predicting mortality and disease severity in pediatric patients with suspected or confirmed infection. We conducted a systematic search of PubMed, EMBASE, the Cochrane Library, and Web of Science. Eleven studies with a total of 172,569 patients were included in the meta-analysis. The pooled sensitivity, specificity, and diagnostic odds ratio of the age-adjusted qSOFA for predicting mortality and disease severity were 0.69 (95% confidence interval [CI] 0.53-0.81), 0.71 (95% CI 0.36-0.91), and 6.57 (95% CI 4.46-9.67), respectively. The area under the summary receiver-operating characteristic curve was 0.733. The pooled sensitivity and specificity for predicting mortality were 0.73 (95% CI 0.66-0.79) and 0.63 (95% CI 0.21-0.92), respectively. The pooled sensitivity and specificity for predicting disease severity were 0.73 (95% CI 0.21-0.97) and 0.72 (95% CI 0.11-0.98), respectively. The performance of the age-adjusted qSOFA for predicting mortality and disease severity was better in emergency department patients than in intensive care unit patients. The age-adjusted qSOFA has moderate predictive power and can help in rapidly identifying at-risk children, but its utility may be limited by its insufficient sensitivity.
Files in This Item:
T202105311.pdf Download
DOI
10.1038/s41598-021-01271-w
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Koo, Chung Mo(구청모)
Kim, Moon Kyu(김문규) ORCID logo https://orcid.org/0000-0001-6186-3991
Kim, Ha Yan(김하얀)
Bae, Go Eun(배고은)
Yoon, Seo Hee(윤서희) ORCID logo https://orcid.org/0000-0002-8361-9815
Eun, So Hyun(은소현)
Lee, Myeongjee(이명지)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187224
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