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Visceral adiposity as a risk factor for lean non-alcoholic fatty liver disease in potential living liver donors
DC Field | Value | Language |
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dc.contributor.author | 이선영 | - |
dc.date.accessioned | 2021-12-28T17:38:43Z | - |
dc.date.available | 2021-12-28T17:38:43Z | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 0815-9319 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187201 | - |
dc.description.abstract | Background and aim: This study aimed to investigate the relationship between hepatic steatosis (HS) evaluated by biopsy and visceral adiposity assessed by computed tomography in lean living liver donor candidates and to determine the risk factors for lean non-alcoholic fatty liver disease (NAFLD). Methods: This retrospective study included 250 lean (body mass index, < 23 kg/m2 ) potential living liver donors (mean age, 31.1 ± 8.6 years; 141 men) who had undergone liver biopsy and abdominal computed tomography between 2017 and 2018. Anthropometry, laboratory parameters, body composition, and the degree of HS were evaluated. Logistic regression was used to identify independent predictors of lean NAFLD. Results: The visceral fat area (VFA) was significantly correlated with the degree of HS in men (r = 0.408; P < 0.001) and women (r = 0.360; P < 0.001). The subcutaneous fat area was significantly correlated with the degree of HS in men (r = 0.398; P < 0.001), but not in women. The skeletal muscle area did not correlate with the degree of HS in either men or women. In the multivariable logistic regression analysis, the VFA (odds ratio [OR], 1.028; 95% confidence interval [CI], 1.013-1.044; P < 0.001) and subcutaneous fat area (OR, 1.016; 95% CI, 1.004-1.028; P = 0.009) were independent risk factors for lean NAFLD in men, and the VFA (OR, 1.036; 95% CI, 1.013-1.059; P = 0.002) was an independent risk factor for lean NAFLD in women. Conclusions: The severity of non-alcoholic fatty liver was positively correlated with visceral fat accumulation in a lean Asian population. Visceral adiposity may be a risk factor for lean NAFLD in potential living liver donors. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Blackwell Scientific Publications | - |
dc.relation.isPartOf | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Visceral adiposity as a risk factor for lean non-alcoholic fatty liver disease in potential living liver donors | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Sunyoung Lee | - |
dc.contributor.googleauthor | Kyoung Won Kim | - |
dc.contributor.googleauthor | Jeongjin Lee | - |
dc.contributor.googleauthor | Taeyong Park | - |
dc.contributor.googleauthor | Seungwoo Khang | - |
dc.contributor.googleauthor | Heeryeol Jeong | - |
dc.contributor.googleauthor | Gi-Won Song | - |
dc.contributor.googleauthor | Sung-Gyu Lee | - |
dc.identifier.doi | 10.1111/jgh.15597 | - |
dc.contributor.localId | A05659 | - |
dc.relation.journalcode | J01417 | - |
dc.identifier.eissn | 1440-1746 | - |
dc.identifier.pmid | 34169561 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/jgh.15597 | - |
dc.subject.keyword | Adipose tissue | - |
dc.subject.keyword | Body mass index | - |
dc.subject.keyword | Non-alcoholic fatty liver disease | - |
dc.subject.keyword | Risk factor | - |
dc.contributor.alternativeName | Lee, Sunyoung | - |
dc.contributor.affiliatedAuthor | 이선영 | - |
dc.citation.volume | 36 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 3212 | - |
dc.citation.endPage | 3218 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol.36(11) : 3212-3218, 2021-11 | - |
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