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Phase I Trial of Intra-arterial Administration of Autologous Bone Marrow-Derived Mesenchymal Stem Cells in Patients with Multiple System Atrophy
DC Field | Value | Language |
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dc.contributor.author | 김동준 | - |
dc.contributor.author | 백경원 | - |
dc.contributor.author | 손영호 | - |
dc.contributor.author | 이양현 | - |
dc.contributor.author | 이필휴 | - |
dc.contributor.author | 정석종 | - |
dc.contributor.author | 정진호 | - |
dc.contributor.author | 유한수 | - |
dc.date.accessioned | 2021-12-28T17:27:51Z | - |
dc.date.available | 2021-12-28T17:27:51Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 1687-966X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187113 | - |
dc.description.abstract | Background: This study is aimed at investigating the safety and tolerability of the intra-arterial administration of autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) in patients with multiple system atrophy- (MSA-) cerebellar type (MSA-C). Methods: This was a single-center, open-label phase I clinical trial in patients with MSA-C. A three-stage dose escalation scheme (low-dose, 3.0 × 105 cells/kg; medium-dose, 6.0 × 105 cells/kg; high-dose, 9.0 × 105 cells/kg) was applied to determine the maximum tolerated dose of intra-arterial administration of BM-MSCs based on the no-observed-adverse-effect level derived from the toxicity study. The occurrence of adverse events was evaluated 1 day before and 1, 14, and 28 days after BM-MSC therapy. Additionally, we assessed changes in the Unified MSA Rating Scale (UMSARS) score 3 months after BM-MSC treatment. Results: One serious adverse drug reaction (ADR) of leptomeningeal enhancement following the intra-arterial BM-MSC administration occurred in one patient in the low-dose group. The safety review of the Internal Monitoring Committee interpreted this as radiological evidence of the blood-brain barrier permeability for MSCs. No other ADRs were observed in the medium- or high-dose groups. In particular, no ischemic lesions on diffusion-weighted images were observed in any of the study participants. Additionally, the medium- and high-dose groups tended to show a slower increase in UMSARS scores than the low-dose group during the 3-month follow-up. Conclusion: The present study confirmed that a single intra-arterial administration of autologous BM-MSCs is a safe and promising neuroprotective strategy in patients with MSA-C. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Hindawi | - |
dc.relation.isPartOf | STEM CELLS INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Phase I Trial of Intra-arterial Administration of Autologous Bone Marrow-Derived Mesenchymal Stem Cells in Patients with Multiple System Atrophy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Seok Jong Chung | - |
dc.contributor.googleauthor | Tae Yong Lee | - |
dc.contributor.googleauthor | Yang Hyun Lee | - |
dc.contributor.googleauthor | KyoungWon Baik | - |
dc.contributor.googleauthor | Jin Ho Jung | - |
dc.contributor.googleauthor | Han Soo Yoo | - |
dc.contributor.googleauthor | Chang Jae Shim | - |
dc.contributor.googleauthor | Hyojin Eom | - |
dc.contributor.googleauthor | Ji-Yeon Hong | - |
dc.contributor.googleauthor | Dong Joon Kim | - |
dc.contributor.googleauthor | Young H Sohn | - |
dc.contributor.googleauthor | Phil Hyu Lee | - |
dc.identifier.doi | 10.1155/2021/9886877 | - |
dc.contributor.localId | A00410 | - |
dc.contributor.localId | A05133 | - |
dc.contributor.localId | A01982 | - |
dc.contributor.localId | A05714 | - |
dc.contributor.localId | A03270 | - |
dc.contributor.localId | A04666 | - |
dc.relation.journalcode | J02685 | - |
dc.identifier.eissn | 1687-9678 | - |
dc.identifier.pmid | 34712335 | - |
dc.contributor.alternativeName | Kim, Dong Joon | - |
dc.contributor.affiliatedAuthor | 김동준 | - |
dc.contributor.affiliatedAuthor | 백경원 | - |
dc.contributor.affiliatedAuthor | 손영호 | - |
dc.contributor.affiliatedAuthor | 이양현 | - |
dc.contributor.affiliatedAuthor | 이필휴 | - |
dc.contributor.affiliatedAuthor | 정석종 | - |
dc.citation.volume | 2021 | - |
dc.citation.startPage | 9886877 | - |
dc.identifier.bibliographicCitation | STEM CELLS INTERNATIONAL, Vol.2021 : 9886877, 2021-10 | - |
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