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Systematic review and meta-analysis of diagnostic performance of CT imaging for assessing resectability of pancreatic ductal adenocarcinoma after neoadjuvant therapy: importance of CT criteria
DC Field | Value | Language |
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dc.contributor.author | 박미숙 | - |
dc.contributor.author | 신재승 | - |
dc.contributor.author | 양현경 | - |
dc.contributor.author | 황신혜 | - |
dc.date.accessioned | 2021-12-28T17:22:03Z | - |
dc.date.available | 2021-12-28T17:22:03Z | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 2366-004X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187069 | - |
dc.description.abstract | Purpose: To assess the CT diagnostic performance for evaluating resectability of pancreatic ductal adenocarcinoma (PDAC) after neoadjuvant therapy and identify the factor(s) that affect(s) diagnostic performance. Methods: Databases were searched to identify studies published from January 1, 2000, to November 5, 2019 that evaluated the CT diagnostic performance for assessing resectability of post-neoadjuvant PDAC. Two reviewers independently extracted data and assessed the study quality. A meta-analysis was performed to obtain summary sensitivity and specificity values using a bivariate random-effects model, and heterogeneity across studies was assessed. Univariable meta-regression analysis was performed with eight variables, including the different CT criteria for resectability, conventional National Comprehensive Cancer Network (NCCN) criteria for upfront surgery, and modified criteria for post-neoadjuvant surgery. Results: Ten studies were included and analyzed. The summary sensitivity and specificity for resectability were 78% (95% CI 68-86%) and 60% (95% CI 44-74%), respectively. No significant heterogeneity was identified (bivariate correlation coefficient ρ = - 1, p-value for hierarchical summary receiver operating characteristics model β = 0.667). The two different CT criteria showed different diagnostic performance (p < 0.01), with higher sensitivity (81% [95% CI 73-90%] vs. 28% [95% CI 15-42%], p < 0.01) and lower specificity (57% [95% CI 41-73%] vs. 90% [95% CI 80-100%], p < 0.01) for the modified criteria. No other variables affected the diagnostic performance. Conclusion: CT criteria were the factors that affected the diagnostic performance. Modification of the conventional criteria improved sensitivity but lowered specificity. Further modifications are required to improve specificity and uniformity. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | ABDOMINAL RADIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Carcinoma, Pancreatic Ductal* / diagnostic imaging | - |
dc.subject.MESH | Carcinoma, Pancreatic Ductal* / surgery | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Neoadjuvant Therapy | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Pancreatic Neoplasms* / diagnostic imaging | - |
dc.subject.MESH | Pancreatic Neoplasms* / pathology | - |
dc.subject.MESH | Pancreatic Neoplasms* / surgery | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Tomography, X-Ray Computed | - |
dc.title | Systematic review and meta-analysis of diagnostic performance of CT imaging for assessing resectability of pancreatic ductal adenocarcinoma after neoadjuvant therapy: importance of CT criteria | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Hyun Kyung Yang | - |
dc.contributor.googleauthor | Mi-Suk Park | - |
dc.contributor.googleauthor | Miyoung Choi | - |
dc.contributor.googleauthor | Jaeseung Shin | - |
dc.contributor.googleauthor | Seung Soo Lee | - |
dc.contributor.googleauthor | Woo Kyoung Jeong | - |
dc.contributor.googleauthor | Shin Hye Hwang | - |
dc.contributor.googleauthor | Sang Hyun Choi | - |
dc.identifier.doi | 10.1007/s00261-021-03198-2 | - |
dc.contributor.localId | A01463 | - |
dc.contributor.localId | A05599 | - |
dc.contributor.localId | A06172 | - |
dc.contributor.localId | A05534 | - |
dc.relation.journalcode | J03314 | - |
dc.identifier.eissn | 2366-0058 | - |
dc.identifier.pmid | 34331549 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00261-021-03198-2 | - |
dc.subject.keyword | Carcinoma | - |
dc.subject.keyword | pancreatic ductal | - |
dc.subject.keyword | Neoadjuvant therapy | - |
dc.subject.keyword | Neoplasm staging | - |
dc.subject.keyword | Pancreatectomy | - |
dc.subject.keyword | Tomography | - |
dc.subject.keyword | X-ray computed | - |
dc.contributor.alternativeName | Park, Mi Sook | - |
dc.contributor.affiliatedAuthor | 박미숙 | - |
dc.contributor.affiliatedAuthor | 신재승 | - |
dc.contributor.affiliatedAuthor | 양현경 | - |
dc.contributor.affiliatedAuthor | 황신혜 | - |
dc.citation.volume | 46 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 5201 | - |
dc.citation.endPage | 5217 | - |
dc.identifier.bibliographicCitation | ABDOMINAL RADIOLOGY, Vol.46(11) : 5201-5217, 2021-11 | - |
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