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Hip Fracture in Patients with Parkinson's Disease and Related Mortality: A Population-Based Study in Korea

Authors
 Je Shik Nam  ;  Yong Wook Kim  ;  Jaeyong Shin  ;  Jee Suk Chang  ;  Seo Yeon Yoon 
Citation
 GERONTOLOGY, Vol.67(5) : 544-553, 2021-10 
Journal Title
GERONTOLOGY
ISSN
 0304-324X 
Issue Date
2021-10
MeSH
Aged ; Cohort Studies ; Female ; Hip Fractures* / epidemiology ; Hip Fractures* / etiology ; Humans ; Male ; Parkinson Disease* / complications ; Parkinson Disease* / epidemiology ; Republic of Korea / epidemiology ; Risk Factors
Keywords
Cohort study ; Hip fracture ; Mortality ; Parkinson’s disease
Abstract
Introduction: Patients with Parkinson's disease (PD) are prone to falls, thereby increasing the risk of fractures and mortality. This population-based study investigated the risk of hip fractures and their effect on mortality in patients with PD in Korea.

Methods: National Health Insurance Service-National Sample Cohort data were used. Patients newly diagnosed with PD between 2006 and 2015 and age- and sex-matched individuals were classified into the PD group and the comparison group, respectively, with a 1:9 ratio. The Cox proportional hazards model was used to calculate hazard ratios (HRs), and the Kaplan-Meier method to identify survivorship.

Results: In total, 26,570 individuals were enrolled in the study: 2,657 in the PD cohort and 23,913 in the matched comparison cohort. The PD group had about a 2 times higher risk of hip fracture than the comparison group (3.95 vs. 1.94%, p < 0.001). According to sex, the difference between the PD and comparison groups for the risk of hip fracture was greater in males than in females. The highest difference in HR for hip fracture between the PD and comparison groups was found in individuals aged between 60 and 69 years. Regarding post-fracture mortality in patients with PD, the mortality risk was twice as high in the patients with hip fracture than in those without. The effect of hip fracture on mortality between these 2 groups was also the highest in individuals aged between 60 and 69 years.

Conclusion: The PD group showed an approximately 2 times higher risk of hip fracture compared with the comparison group, and the post-fracture mortality rate was 2 times higher in the patients with PD with hip fracture than in those without. Those aged 60-69 years were associated with the highest risk of hip fracture and post-hip fracture mortality among patients with PD.
Full Text
https://www.karger.com/Article/Abstract/513730
DOI
10.1159/000513730
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yong Wook(김용욱) ORCID logo https://orcid.org/0000-0002-5234-2454
Chang, Jee Suk(장지석) ORCID logo https://orcid.org/0000-0001-7685-3382
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187042
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