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Evaluation of the International Society for Cutaneous Lymphoma Algorithm for the Diagnosis of Early Mycosis Fungoides

Authors
 Hyang-Joo Ryu  ;  Sun-Il Kim  ;  Hyung-Ook Jang  ;  Se-Hoon Kim  ;  Sang-Ho Oh  ;  Sujin Park  ;  Sang-Kyum Kim 
Citation
 CELLS, Vol.10(10) : 2758, 2021-10 
Journal Title
CELLS(Cells)
ISSN
 2073-4409 
Issue Date
2021-10
Keywords
CD5 ; CD7 ; ISCL algorithm ; TCR-β ; TCR-γ ; mycosis fungoides
Abstract
The International Society for Cutaneous Lymphoma (ISCL) proposes a diagnostic algorithm for early mycosis fungoides (MF) that includes clinical, histological, immunophenotypical, and molecular criteria. Here, we analyzed the immunologic markers and features of T-cell clonality in 38 early MF cases and 22 non-MF cases to validate the ISCL algorithm. We found that CD5 and CD7 expression differed significantly between early MF and non-MF cases, with epidermal discordance of CD7 expression more frequently identified in early MF. Notably, increasing the cut-off value for CD7 expression from 10% to 22.5% improved its sensitivity. Furthermore, TCR-γ and β chain rearrangements were more frequently detected in early MF than in non-MF cases. Based on these findings, we propose CD5 and CD7 deficiency as mandatory immunopathologic criteria and PCR-based testing for TCR-γ and β chains as required molecular/biologic criteria to improve the efficiency of early MF diagnosis using the ISCL algorithm.
Files in This Item:
T202104957.pdf Download
DOI
10.3390/cells10102758
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sang Kyum(김상겸) ORCID logo https://orcid.org/0000-0003-0768-9923
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
Ryu, Hyang-Joo(류향주)
Oh, Sang Ho(오상호) ORCID logo https://orcid.org/0000-0002-4477-1400
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187038
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