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Evaluation of the International Society for Cutaneous Lymphoma Algorithm for the Diagnosis of Early Mycosis Fungoides
DC Field | Value | Language |
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dc.contributor.author | 김상겸 | - |
dc.contributor.author | 김세훈 | - |
dc.contributor.author | 류향주 | - |
dc.contributor.author | 오상호 | - |
dc.date.accessioned | 2021-12-28T17:18:30Z | - |
dc.date.available | 2021-12-28T17:18:30Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 2073-4409 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187038 | - |
dc.description.abstract | The International Society for Cutaneous Lymphoma (ISCL) proposes a diagnostic algorithm for early mycosis fungoides (MF) that includes clinical, histological, immunophenotypical, and molecular criteria. Here, we analyzed the immunologic markers and features of T-cell clonality in 38 early MF cases and 22 non-MF cases to validate the ISCL algorithm. We found that CD5 and CD7 expression differed significantly between early MF and non-MF cases, with epidermal discordance of CD7 expression more frequently identified in early MF. Notably, increasing the cut-off value for CD7 expression from 10% to 22.5% improved its sensitivity. Furthermore, TCR-γ and β chain rearrangements were more frequently detected in early MF than in non-MF cases. Based on these findings, we propose CD5 and CD7 deficiency as mandatory immunopathologic criteria and PCR-based testing for TCR-γ and β chains as required molecular/biologic criteria to improve the efficiency of early MF diagnosis using the ISCL algorithm. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | CELLS(Cells) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Evaluation of the International Society for Cutaneous Lymphoma Algorithm for the Diagnosis of Early Mycosis Fungoides | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Hyang-Joo Ryu | - |
dc.contributor.googleauthor | Sun-Il Kim | - |
dc.contributor.googleauthor | Hyung-Ook Jang | - |
dc.contributor.googleauthor | Se-Hoon Kim | - |
dc.contributor.googleauthor | Sang-Ho Oh | - |
dc.contributor.googleauthor | Sujin Park | - |
dc.contributor.googleauthor | Sang-Kyum Kim | - |
dc.identifier.doi | 10.3390/cells10102758 | - |
dc.contributor.localId | A00520 | - |
dc.contributor.localId | A00610 | - |
dc.contributor.localId | A06168 | - |
dc.contributor.localId | A02370 | - |
dc.relation.journalcode | J03774 | - |
dc.identifier.pmid | 34685738 | - |
dc.subject.keyword | CD5 | - |
dc.subject.keyword | CD7 | - |
dc.subject.keyword | ISCL algorithm | - |
dc.subject.keyword | TCR-β | - |
dc.subject.keyword | TCR-γ | - |
dc.subject.keyword | mycosis fungoides | - |
dc.contributor.alternativeName | Kim, Sang Kyum | - |
dc.contributor.affiliatedAuthor | 김상겸 | - |
dc.contributor.affiliatedAuthor | 김세훈 | - |
dc.contributor.affiliatedAuthor | 류향주 | - |
dc.contributor.affiliatedAuthor | 오상호 | - |
dc.citation.volume | 10 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2758 | - |
dc.identifier.bibliographicCitation | CELLS, Vol.10(10) : 2758, 2021-10 | - |
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