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Tissue-specific biomarkers in gingival crevicular fluid are correlated with external root resorption caused by constant mechanical load: an in vivo study

Authors
 Gui-Yue Huang  ;  Sung-Hwan Choi  ;  Hwi-Dong Jung  ;  Hyun Sil Kim  ;  Chung-Ju Hwang  ;  Kee-Joon Lee 
Citation
 CLINICAL ORAL INVESTIGATIONS, Vol.25(11) : 6321-6333, 2021-11 
Journal Title
CLINICAL ORAL INVESTIGATIONS
ISSN
 1432-6981 
Issue Date
2021-11
MeSH
Adult ; Bicuspid ; Biomarkers / analysis ; Female ; Gingival Crevicular Fluid / chemistry ; Humans ; Male ; Root Resorption* ; Tooth Movement Techniques ; Young Adult
Keywords
CEMP-1 ; CTX-I ; DPP ; External root resorption ; GCF
Abstract
Objectives: This study investigated the association of changes in cementum protein-1 (CEMP-1), dentine phosphoprotein (DPP), and c-terminal cross-linked telopeptide of type I collagen (CTX-I) levels in human gingival crevicular fluid (GCF) under constant load with external root resorption volume and amount of tooth movement.

Materials and methods: In total, 11 healthy adult patients (mean age, 23.5 years [range, 18.3-37.7]; four men and seven women) were enrolled. GCF samples were obtained from premolars at T0, T1 (1 day), T2 (1 week), T3 (2 weeks), T4 (4 weeks), and T5 (8 weeks) under constant 100-gm buccal tipping force. Opposite premolars were used as controls. Teeth were extracted at T5, followed by quantification of external root resorption volume and histological analysis.

Results: In the test group, T5/T0 ratios of CEMP-1 and DPP levels, differential CEMP-1 levels between T5 and T0, and differential DPP levels between T2 and T0 correlated positively with root resorption volume (r = 0.734, 0.730, 0.627, and 0.612, respectively, all p < 0.05). CEMP-1 levels at T0 and T3 correlated negatively with root resorption volume (r = -0.603 and -0.706; all p < 0.05). CTX-I levels at T5 correlated positively with the amount of tooth movement (r = 0.848, p < 0.01).

Conclusions: Alterations in CEMP-1 and DPP levels in human GCF at specific timepoints during orthodontic treatment may be associated with different degrees of external root resorption.

Clinical relevance: This study demonstrates that changes in the levels of tissue-specific biomarkers in GCF may facilitate early detection of external root resorption during orthodontic tooth movement.
Full Text
https://link.springer.com/article/10.1007%2Fs00784-021-03932-6
DOI
10.1007/s00784-021-03932-6
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyun Sil(김현실) ORCID logo https://orcid.org/0000-0003-3614-1764
Lee, Kee Joon(이기준) ORCID logo https://orcid.org/0000-0002-0782-3128
Jung, Hwi Dong(정휘동) ORCID logo https://orcid.org/0000-0003-1025-8323
Choi, Sung Hwan(최성환) ORCID logo https://orcid.org/0000-0002-1150-0268
Hwang, Chung Ju(황충주) ORCID logo https://orcid.org/0000-0003-3024-4551
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187024
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