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Short-Term Outcomes following "Switching" to Monthly Ranibizumab in Neovascular Age-Related Macular Degeneration Showing Insufficient Response to Bimonthly Aflibercept

Authors
 Jong Suk Lee  ;  Hyun Goo Kang  ;  Christopher Seungkyu Lee  ;  Se Joon Woo 
Citation
 JOURNAL OF OPHTHALMOLOGY, Vol.2021 : 5547686, 2021-08 
Journal Title
JOURNAL OF OPHTHALMOLOGY
ISSN
 2090-004X 
Issue Date
2021-08
Abstract
Background/Objectives. To evaluate the efficacy of switching to monthly ranibizumab in neovascular age-related macular de generation (nAMD) showing an insufficient response to bimonthly aflibercept. Subjects/Methods. A total of 13 nAMD eyes
showing an insufficient treatment response to three successive aflibercept injections were enrolled through a retrospective chart
review. After switching, three consecutive monthly intravitreal ranibizumab injections were performed. *e main outcome
measurements included the best-corrected visual acuity (BCVA), central retinal thickness (CRT), presence of intraretinal fluid
(IRF), and subretinal fluid (SRF) using optical coherence tomography (OCT) and were measured every month. Results. CRT and
logMAR VA were 349.62 ± 223.51 μm and 0.50 ± 0.23 at the baseline and 274.69 ± 148.77 μm and 0.46 ± 0.24, 311.54 ± 192.90 μm
and 0.45 ± 0.20 at 1 month after the first and third ranibizumab injections, respectively. *e CRT decrease during three
ranibizumab injections was statistically significant (38.08 ± 69.52 μm, p � 0.033). Change in VA was not statistically significant.
*e percentage of eyes with SRF was 100% at baseline and 53.8%, 76.9%, and 69.2% one month after each ranibizumab injections.
*e percentage of eyes with IRF was 38.5% at baseline and 23.1%, 23.1%, and 15.4%, respectively, after switching. Conclusion.
Switching to monthly ranibizumab in nAMD showing an insufficient response to bimonthly aflibercept led to immediate
anatomical improvement. It can be considered in countries where the healthcare insurance system limits the minimum injection
interval of aflibercept.
Files in This Item:
T202104885.pdf Download
DOI
10.1155/2021/5547686
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hyun Goo(강현구) ORCID logo https://orcid.org/0000-0001-8359-9618
Lee, Christopher Seungkyu(이승규) ORCID logo https://orcid.org/0000-0001-5054-9470
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/186972
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