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(-)-Gallocatechin gallate from green tea rescues cognitive impairment through restoring hippocampal silent synapses in post-menopausal depression

Authors
 Sukjin Ko  ;  Won Seuk Jang  ;  Ji-Hyun Jeong  ;  Ji Woong Ahn  ;  Young-Hwan Kim  ;  Sohyun Kim  ;  Hyeon Kyeong Chae  ;  Seungsoo Chung 
Citation
 SCIENTIFIC REPORTS, Vol.11(1) : 910, 2021-01 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2021-01
MeSH
Animals ; Antioxidants / pharmacology ; Catechin / analogs & derivatives* ; Catechin / metabolism ; Catechin / pharmacology ; Cognition Disorders / diet therapy ; Cognitive Dysfunction / diet therapy* ; Depression / diet therapy ; Depression / metabolism ; Dietary Supplements ; Female ; Hippocampus / drug effects ; Hippocampus / metabolism ; Plant Extracts / pharmacology ; Postmenopause / psychology* ; Rats ; Rats, Sprague-Dawley ; Synapses / drug effects ; Tea / metabolism
Abstract
Post-menopausal depression (PMD) is a common psychological disorder accompanied by a cognitive deficit, which is caused by a series of uncontrolled emotional disruptions by strong environmental stressors during menopause. To overcome PMD-induced cognitive deficit, Green tea has been suggested as a dietary supplement because of its ameliorating effect on cognitive dysfunction induced by normal aging or neurodegenerative syndromes; however, its clinical use to improve PMD-accompanied cognitive deficit is still limited due to the controversy for the active ingredients and ambiguous mechanism of its action. Here, we developed modified high-temperature-processed green tea extract (HTP-GTE), which showed lower neuronal toxicity than the conventional green tea extract (GTE). We also demonstrated that HTP-GTE administration prevented the development of learned helplessness (LH) in a rat post-menopausal model. Additionally, HTP-GTE improved LH-induced cognitive impairments simultaneously with rescued the long-term synaptic plasticity. This occurred via the restoration of silent synapse formation by increasing the hippocampal BDNF-tyrosine receptor kinase B pathway in the helpless ovariectomized (OVX) rats. Likewise, we also identified that (-)-gallocatechin gallate was the main contributor of the HTP-GTE effect. Our findings suggested that HTP-GTE has a potential as a preventive nutritional supplement to ameliorate cognitive dysfunctions associated with PMD.
Files in This Item:
T202104872.pdf Download
DOI
10.1038/s41598-020-79287-x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Ko, Suk Jin(고석진)
Chang, Won Seok(장원석) ORCID logo https://orcid.org/0000-0002-4925-3549
Chung, Seung Soo(정승수) ORCID logo https://orcid.org/0000-0002-3119-9628
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/186959
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