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(-)-Gallocatechin gallate from green tea rescues cognitive impairment through restoring hippocampal silent synapses in post-menopausal depression

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dc.contributor.author고석진-
dc.contributor.author장원석-
dc.contributor.author정승수-
dc.date.accessioned2021-12-28T17:08:56Z-
dc.date.available2021-12-28T17:08:56Z-
dc.date.issued2021-01-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/186959-
dc.description.abstractPost-menopausal depression (PMD) is a common psychological disorder accompanied by a cognitive deficit, which is caused by a series of uncontrolled emotional disruptions by strong environmental stressors during menopause. To overcome PMD-induced cognitive deficit, Green tea has been suggested as a dietary supplement because of its ameliorating effect on cognitive dysfunction induced by normal aging or neurodegenerative syndromes; however, its clinical use to improve PMD-accompanied cognitive deficit is still limited due to the controversy for the active ingredients and ambiguous mechanism of its action. Here, we developed modified high-temperature-processed green tea extract (HTP-GTE), which showed lower neuronal toxicity than the conventional green tea extract (GTE). We also demonstrated that HTP-GTE administration prevented the development of learned helplessness (LH) in a rat post-menopausal model. Additionally, HTP-GTE improved LH-induced cognitive impairments simultaneously with rescued the long-term synaptic plasticity. This occurred via the restoration of silent synapse formation by increasing the hippocampal BDNF-tyrosine receptor kinase B pathway in the helpless ovariectomized (OVX) rats. Likewise, we also identified that (-)-gallocatechin gallate was the main contributor of the HTP-GTE effect. Our findings suggested that HTP-GTE has a potential as a preventive nutritional supplement to ameliorate cognitive dysfunctions associated with PMD.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnimals-
dc.subject.MESHAntioxidants / pharmacology-
dc.subject.MESHCatechin / analogs & derivatives*-
dc.subject.MESHCatechin / metabolism-
dc.subject.MESHCatechin / pharmacology-
dc.subject.MESHCognition Disorders / diet therapy-
dc.subject.MESHCognitive Dysfunction / diet therapy*-
dc.subject.MESHDepression / diet therapy-
dc.subject.MESHDepression / metabolism-
dc.subject.MESHDietary Supplements-
dc.subject.MESHFemale-
dc.subject.MESHHippocampus / drug effects-
dc.subject.MESHHippocampus / metabolism-
dc.subject.MESHPlant Extracts / pharmacology-
dc.subject.MESHPostmenopause / psychology*-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHSynapses / drug effects-
dc.subject.MESHTea / metabolism-
dc.title(-)-Gallocatechin gallate from green tea rescues cognitive impairment through restoring hippocampal silent synapses in post-menopausal depression-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Physiology (생리학교실)-
dc.contributor.googleauthorSukjin Ko-
dc.contributor.googleauthorWon Seuk Jang-
dc.contributor.googleauthorJi-Hyun Jeong-
dc.contributor.googleauthorJi Woong Ahn-
dc.contributor.googleauthorYoung-Hwan Kim-
dc.contributor.googleauthorSohyun Kim-
dc.contributor.googleauthorHyeon Kyeong Chae-
dc.contributor.googleauthorSeungsoo Chung-
dc.identifier.doi10.1038/s41598-020-79287-x-
dc.contributor.localIdA00120-
dc.contributor.localIdA04793-
dc.contributor.localIdA03643-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid33441611-
dc.contributor.alternativeNameKo, Suk Jin-
dc.contributor.affiliatedAuthor고석진-
dc.contributor.affiliatedAuthor장원석-
dc.contributor.affiliatedAuthor정승수-
dc.citation.volume11-
dc.citation.number1-
dc.citation.startPage910-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.11(1) : 910, 2021-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers

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