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(-)-Gallocatechin gallate from green tea rescues cognitive impairment through restoring hippocampal silent synapses in post-menopausal depression
DC Field | Value | Language |
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dc.contributor.author | 고석진 | - |
dc.contributor.author | 장원석 | - |
dc.contributor.author | 정승수 | - |
dc.date.accessioned | 2021-12-28T17:08:56Z | - |
dc.date.available | 2021-12-28T17:08:56Z | - |
dc.date.issued | 2021-01 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186959 | - |
dc.description.abstract | Post-menopausal depression (PMD) is a common psychological disorder accompanied by a cognitive deficit, which is caused by a series of uncontrolled emotional disruptions by strong environmental stressors during menopause. To overcome PMD-induced cognitive deficit, Green tea has been suggested as a dietary supplement because of its ameliorating effect on cognitive dysfunction induced by normal aging or neurodegenerative syndromes; however, its clinical use to improve PMD-accompanied cognitive deficit is still limited due to the controversy for the active ingredients and ambiguous mechanism of its action. Here, we developed modified high-temperature-processed green tea extract (HTP-GTE), which showed lower neuronal toxicity than the conventional green tea extract (GTE). We also demonstrated that HTP-GTE administration prevented the development of learned helplessness (LH) in a rat post-menopausal model. Additionally, HTP-GTE improved LH-induced cognitive impairments simultaneously with rescued the long-term synaptic plasticity. This occurred via the restoration of silent synapse formation by increasing the hippocampal BDNF-tyrosine receptor kinase B pathway in the helpless ovariectomized (OVX) rats. Likewise, we also identified that (-)-gallocatechin gallate was the main contributor of the HTP-GTE effect. Our findings suggested that HTP-GTE has a potential as a preventive nutritional supplement to ameliorate cognitive dysfunctions associated with PMD. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antioxidants / pharmacology | - |
dc.subject.MESH | Catechin / analogs & derivatives* | - |
dc.subject.MESH | Catechin / metabolism | - |
dc.subject.MESH | Catechin / pharmacology | - |
dc.subject.MESH | Cognition Disorders / diet therapy | - |
dc.subject.MESH | Cognitive Dysfunction / diet therapy* | - |
dc.subject.MESH | Depression / diet therapy | - |
dc.subject.MESH | Depression / metabolism | - |
dc.subject.MESH | Dietary Supplements | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hippocampus / drug effects | - |
dc.subject.MESH | Hippocampus / metabolism | - |
dc.subject.MESH | Plant Extracts / pharmacology | - |
dc.subject.MESH | Postmenopause / psychology* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Synapses / drug effects | - |
dc.subject.MESH | Tea / metabolism | - |
dc.title | (-)-Gallocatechin gallate from green tea rescues cognitive impairment through restoring hippocampal silent synapses in post-menopausal depression | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학교실) | - |
dc.contributor.googleauthor | Sukjin Ko | - |
dc.contributor.googleauthor | Won Seuk Jang | - |
dc.contributor.googleauthor | Ji-Hyun Jeong | - |
dc.contributor.googleauthor | Ji Woong Ahn | - |
dc.contributor.googleauthor | Young-Hwan Kim | - |
dc.contributor.googleauthor | Sohyun Kim | - |
dc.contributor.googleauthor | Hyeon Kyeong Chae | - |
dc.contributor.googleauthor | Seungsoo Chung | - |
dc.identifier.doi | 10.1038/s41598-020-79287-x | - |
dc.contributor.localId | A00120 | - |
dc.contributor.localId | A04793 | - |
dc.contributor.localId | A03643 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 33441611 | - |
dc.contributor.alternativeName | Ko, Suk Jin | - |
dc.contributor.affiliatedAuthor | 고석진 | - |
dc.contributor.affiliatedAuthor | 장원석 | - |
dc.contributor.affiliatedAuthor | 정승수 | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 910 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.11(1) : 910, 2021-01 | - |
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