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Association of perioperative serum carcinoembryonic antigen level and recurrence in low-risk stage IIA colon cancer

Authors
 Han-Gil Kim  ;  Seung Yoon Yang  ;  Yoon Dae Han  ;  Min Soo Cho  ;  Byung Soh Min  ;  Kang Young Lee  ;  Nam Kyu Kim  ;  Hyuk Hur 
Citation
 PLOS ONE, Vol.16(6) : e0252566, 2021-06 
Journal Title
PLOS ONE
Issue Date
2021-06
MeSH
Adult ; Aged ; Aged, 80 and over ; Carcinoembryonic Antigen / blood* ; Colonic Neoplasms / blood* ; Colonic Neoplasms / pathology ; Disease-Free Survival ; Female ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Recurrence, Local / blood ; Neoplasm Recurrence, Local / pathology ; Retrospective Studies
Abstract
Background: The purpose is to investigate prognosis according to serum CEA levels before and after surgery in patients with stage IIA colon cancer who do not show high-risk features.

Methods: Among the patients diagnosed with colon adenocarcinoma between April 2011 and December 2017, 462 patients were confirmed as low-risk stage IIA after surgery and enrolled. The ROC curve was used to determine cut-off values of pre- and postoperative CEA. Patients were classified into three groups using these new cut-off values.

Results: All recurrence occurred in 52 of 463 patients (11.2%). However, recurrence in group H was 15.9%, which was slightly higher than the other two groups (P = 0.04). Group L and M showed 10.5% and 12.8% overall survival, group H was higher at 21.0% (P = 0.005). Recurrence was the only risk factor in group H was significantly higher in group L (HR 2.008, 95% CI, 1.123-3.589, P = 0.019). Mortality was similar to recurrence (HR 1.975, 95% CI 1.091-3.523, P = 0.044).

Conclusion: Among patients with low-risk stage IIA colon cancer, recurrence and mortality rates were higher when perioperative serum CEA levels were above a certain level. Therefore, high CEA level should be considered a high-risk feature and adjuvant chemotherapy should be performed.
Files in This Item:
T202104869.pdf Download
DOI
10.1371/journal.pone.0252566
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Min, Byung Soh(민병소) ORCID logo https://orcid.org/0000-0003-0180-8565
Yang, Seung Yoon(양승윤) ORCID logo https://orcid.org/0000-0001-8129-7712
Lee, Kang Young(이강영)
Cho, Min Soo(조민수)
Han, Yoon Dae(한윤대) ORCID logo https://orcid.org/0000-0002-2136-3578
Hur, Hyuk(허혁) ORCID logo https://orcid.org/0000-0002-9864-7229
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/186957
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