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Association of perioperative serum carcinoembryonic antigen level and recurrence in low-risk stage IIA colon cancer
DC Field | Value | Language |
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dc.contributor.author | 김남규 | - |
dc.contributor.author | 민병소 | - |
dc.contributor.author | 양승윤 | - |
dc.contributor.author | 이강영 | - |
dc.contributor.author | 조민수 | - |
dc.contributor.author | 한윤대 | - |
dc.contributor.author | 허혁 | - |
dc.date.accessioned | 2021-12-28T17:08:37Z | - |
dc.date.available | 2021-12-28T17:08:37Z | - |
dc.date.issued | 2021-06 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186957 | - |
dc.description.abstract | Background: The purpose is to investigate prognosis according to serum CEA levels before and after surgery in patients with stage IIA colon cancer who do not show high-risk features. Methods: Among the patients diagnosed with colon adenocarcinoma between April 2011 and December 2017, 462 patients were confirmed as low-risk stage IIA after surgery and enrolled. The ROC curve was used to determine cut-off values of pre- and postoperative CEA. Patients were classified into three groups using these new cut-off values. Results: All recurrence occurred in 52 of 463 patients (11.2%). However, recurrence in group H was 15.9%, which was slightly higher than the other two groups (P = 0.04). Group L and M showed 10.5% and 12.8% overall survival, group H was higher at 21.0% (P = 0.005). Recurrence was the only risk factor in group H was significantly higher in group L (HR 2.008, 95% CI, 1.123-3.589, P = 0.019). Mortality was similar to recurrence (HR 1.975, 95% CI 1.091-3.523, P = 0.044). Conclusion: Among patients with low-risk stage IIA colon cancer, recurrence and mortality rates were higher when perioperative serum CEA levels were above a certain level. Therefore, high CEA level should be considered a high-risk feature and adjuvant chemotherapy should be performed. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Carcinoembryonic Antigen / blood* | - |
dc.subject.MESH | Colonic Neoplasms / blood* | - |
dc.subject.MESH | Colonic Neoplasms / pathology | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Neoplasm Recurrence, Local / blood | - |
dc.subject.MESH | Neoplasm Recurrence, Local / pathology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Association of perioperative serum carcinoembryonic antigen level and recurrence in low-risk stage IIA colon cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Han-Gil Kim | - |
dc.contributor.googleauthor | Seung Yoon Yang | - |
dc.contributor.googleauthor | Yoon Dae Han | - |
dc.contributor.googleauthor | Min Soo Cho | - |
dc.contributor.googleauthor | Byung Soh Min | - |
dc.contributor.googleauthor | Kang Young Lee | - |
dc.contributor.googleauthor | Nam Kyu Kim | - |
dc.contributor.googleauthor | Hyuk Hur | - |
dc.identifier.doi | 10.1371/journal.pone.0252566 | - |
dc.contributor.localId | A00353 | - |
dc.contributor.localId | A01402 | - |
dc.contributor.localId | A05359 | - |
dc.contributor.localId | A02640 | - |
dc.contributor.localId | A03817 | - |
dc.contributor.localId | A04313 | - |
dc.contributor.localId | A04373 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 34106954 | - |
dc.contributor.alternativeName | Kim, Nam Kyu | - |
dc.contributor.affiliatedAuthor | 김남규 | - |
dc.contributor.affiliatedAuthor | 민병소 | - |
dc.contributor.affiliatedAuthor | 양승윤 | - |
dc.contributor.affiliatedAuthor | 이강영 | - |
dc.contributor.affiliatedAuthor | 조민수 | - |
dc.contributor.affiliatedAuthor | 한윤대 | - |
dc.contributor.affiliatedAuthor | 허혁 | - |
dc.citation.volume | 16 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | e0252566 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.16(6) : e0252566, 2021-06 | - |
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