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C-reactive protein is associated with postoperative outcomes in patients with intestinal Behçet's disease

Authors
 Eun Ae Kang  ;  Jung Won Park  ;  Yehyun Park  ;  Soo Jung Park  ;  Tae Il Kim  ;  Won Ho Kim  ;  Min Soo Cho  ;  Jae Hee Cheon 
Citation
 BMC GASTROENTEROLOGY, Vol.21(1) : 362, 2021-10 
Journal Title
BMC GASTROENTEROLOGY
Issue Date
2021-10
MeSH
Adolescent ; Adult ; Aged ; Behcet Syndrome* / surgery ; C-Reactive Protein* / analysis ; Child ; Female ; Humans ; Intestinal Diseases* / surgery ; Male ; Middle Aged ; Postoperative Period ; Retrospective Studies ; Young Adult
Keywords
CRP ; Intestinal Behçet’s disease ; complication ; prognosis ; surgery
Abstract
Background: Patients with intestinal Behçet's disease (BD) frequently undergo intestinal resections, which significantly affects postoperative morbidity and mortality. The aim of this study was to identify the association between C-reactive protein (CRP) levels and postoperative outcomes in patients with intestinal BD who underwent surgical bowel resection.

Methods: Patients who were diagnosed with intestinal BD and underwent intestinal surgery due to BD at Severance Hospital between November 2005 and April 2018 were retrospectively investigated. Clinical relapse was defined as a disease activity index of BD (DAIBD) > 40, existence of newly added medications, re-hospitalization, or re-operation related to intestinal BD. The relationship between CRP level and postoperative outcomes was analyzed, and a receiver operating characteristic (ROC) curve was drawn to specify a cut-off value.

Results: Ninety patients with intestinal BD were included. Among them, 44 were male (48.9%), and the median age at diagnosis was 38 years (range, 11-69 years). The median total disease follow-up duration was 130 months (range, 3-460 months). Forty patients (44.4%) underwent laparoscopic surgery. A higher CRP level immediately after surgery was significantly associated with postoperative complications (OR 1.01, 95% CI 1.004-1.018, p < 0.01), re-operation (hazard ratio [HR] 1.01, 95% CI 1.005-1.020, p < 0.01), and re-admission (HR 1.01, 95% CI 1.006-1.017 p < 0.01). The ROC curve showed that CRP predicts the risk of postoperative complications (p < 0.01) at a cut-off value of 41.9% with a sensitivity of 60.0% and specificity of 67.7%.

Conclusions: Postoperative CRP levels in patients with intestinal BD undergoing surgical resection were associated with postoperative outcomes.
Files in This Item:
T202104729.pdf Download
DOI
10.1186/s12876-021-01922-2
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Ae(강은애)
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Kim, Tae Il(김태일) ORCID logo https://orcid.org/0000-0003-4807-890X
Park, Soo Jung(박수정)
Park, Yehyun(박예현) ORCID logo https://orcid.org/0000-0001-8811-0631
Park, Jung Won(박정원)
Cho, Min Soo(조민수)
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/186845
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