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Characteristics and Early Recurrence of Hepatocellular Carcinomas Categorized as LR-M: Comparison with Those Categorized as LR-4 or 5

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dc.contributor.author김명진-
dc.contributor.author김승섭-
dc.contributor.author박미숙-
dc.contributor.author신재승-
dc.contributor.author이선영-
dc.contributor.author정용은-
dc.contributor.author최진영-
dc.date.accessioned2021-12-28T16:41:09Z-
dc.date.available2021-12-28T16:41:09Z-
dc.date.issued2021-11-
dc.identifier.issn1053-1807-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/186751-
dc.description.abstractBackground: According to the Liver Imaging Reporting and Data System (LI-RADS), the LI-RADS category M (LR-M), which are probably or definitely malignant but are not specific for hepatocellular carcinomas (HCCs), does not exclude HCCs. A gap in knowledge remains, including their characteristics and recurrence of HCCs categorized as LR-M. Purpose: To compare the characteristics of HCCs categorized as LR-M with HCCs categorized as LR-4 or LR-5 (LR-4/5) using the LI-RADS version 2018 and evaluate the relationship of these categories with the risk of early recurrence after curative resections of single HCCs. Study type: Retrospective. Subjects: Two hundred and eighty-one patients (mean age, 57 years; 191 men and 90 women) who underwent curative resections for single HCCs and preoperative contrast-enhanced MRI between 2015 and 2017. Field strength/sequence: 3T Dual gradient-echo T1 WI with in- and opposed-phase, turbo spin-echo T2 WI, diffusion-weighted echo-planar images, and three-dimensional gradient-echo T1 WI before and after administration of contrast agent. Assessment: MRI features according to the LI-RADS version 2018 were evaluated and LI-RADS category were assigned for each observation. Clinical, imaging, and histopathological features were compared based on LI-RADS categorization. Early recurrence rates (<2 years) and associated factors were also evaluated. Statistical tests: Fisher's exact test, two-sample t test after satisfying assumption of normality through Shapiro-Wilk test, Fleiss κ coefficient, Cox proportional hazards regression analysis, Kaplan-Meier method, and log-rank test. Results: Forty-one HCCs (14.6%) were categorized as LR-M and 240 HCCs (85.4%) were categorized as LR-4/5. LR-M HCCs showed poorer differentiation than LR-4/5 HCCs. In the multivariate analysis, the LR-M category was an independent predictor for early recurrence (hazard ratio, 1.904; 95% confidence interval, 1.024-3.542; P < 0.05). Early recurrence rates were significantly higher in patients with LR-M HCCs than in patients with LR-4/5 HCCs (32.0% vs. 18.4%, respectively, P < 0 05). Data conclusion: Compared to LR-4/5 HCCs, LR-M HCCs were associated with poorer tumor differentiation and higher early recurrence rates after curative resections of single HCCs. Level of evidence: 3 Technical Efficacy Stage: 2.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-Liss-
dc.relation.isPartOfJOURNAL OF MAGNETIC RESONANCE IMAGING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHCarcinoma, Hepatocellular* / diagnostic imaging-
dc.subject.MESHContrast Media-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLiver Neoplasms* / diagnostic imaging-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Recurrence, Local / diagnostic imaging-
dc.subject.MESHRetrospective Studies-
dc.titleCharacteristics and Early Recurrence of Hepatocellular Carcinomas Categorized as LR-M: Comparison with Those Categorized as LR-4 or 5-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorJaeseung Shin-
dc.contributor.googleauthorSunyoung Lee-
dc.contributor.googleauthorSeung-Seob Kim-
dc.contributor.googleauthorYong Eun Chung-
dc.contributor.googleauthorJin-Young Choi-
dc.contributor.googleauthorMi-Suk Park-
dc.contributor.googleauthorMyeong-Jin Kim-
dc.identifier.doi10.1002/jmri.27650-
dc.contributor.localIdA00426-
dc.contributor.localIdA05097-
dc.contributor.localIdA01463-
dc.contributor.localIdA05599-
dc.contributor.localIdA05659-
dc.contributor.localIdA03662-
dc.contributor.localIdA04200-
dc.relation.journalcodeJ01567-
dc.identifier.eissn1522-2586-
dc.identifier.pmid33891790-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1002/jmri.27650-
dc.subject.keyworddiagnosis-
dc.subject.keywordhepatocellular carcinoma-
dc.subject.keywordmagnetic resonance imaging-
dc.subject.keywordprognosis-
dc.contributor.alternativeNameKim, Myeong Jin-
dc.contributor.affiliatedAuthor김명진-
dc.contributor.affiliatedAuthor김승섭-
dc.contributor.affiliatedAuthor박미숙-
dc.contributor.affiliatedAuthor신재승-
dc.contributor.affiliatedAuthor이선영-
dc.contributor.affiliatedAuthor정용은-
dc.contributor.affiliatedAuthor최진영-
dc.citation.volume54-
dc.citation.number5-
dc.citation.startPage1446-
dc.citation.endPage1454-
dc.identifier.bibliographicCitationJOURNAL OF MAGNETIC RESONANCE IMAGING, Vol.54(5) : 1446-1454, 2021-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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