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Characteristics and Early Recurrence of Hepatocellular Carcinomas Categorized as LR-M: Comparison with Those Categorized as LR-4 or 5
DC Field | Value | Language |
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dc.contributor.author | 김명진 | - |
dc.contributor.author | 김승섭 | - |
dc.contributor.author | 박미숙 | - |
dc.contributor.author | 신재승 | - |
dc.contributor.author | 이선영 | - |
dc.contributor.author | 정용은 | - |
dc.contributor.author | 최진영 | - |
dc.date.accessioned | 2021-12-28T16:41:09Z | - |
dc.date.available | 2021-12-28T16:41:09Z | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 1053-1807 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186751 | - |
dc.description.abstract | Background: According to the Liver Imaging Reporting and Data System (LI-RADS), the LI-RADS category M (LR-M), which are probably or definitely malignant but are not specific for hepatocellular carcinomas (HCCs), does not exclude HCCs. A gap in knowledge remains, including their characteristics and recurrence of HCCs categorized as LR-M. Purpose: To compare the characteristics of HCCs categorized as LR-M with HCCs categorized as LR-4 or LR-5 (LR-4/5) using the LI-RADS version 2018 and evaluate the relationship of these categories with the risk of early recurrence after curative resections of single HCCs. Study type: Retrospective. Subjects: Two hundred and eighty-one patients (mean age, 57 years; 191 men and 90 women) who underwent curative resections for single HCCs and preoperative contrast-enhanced MRI between 2015 and 2017. Field strength/sequence: 3T Dual gradient-echo T1 WI with in- and opposed-phase, turbo spin-echo T2 WI, diffusion-weighted echo-planar images, and three-dimensional gradient-echo T1 WI before and after administration of contrast agent. Assessment: MRI features according to the LI-RADS version 2018 were evaluated and LI-RADS category were assigned for each observation. Clinical, imaging, and histopathological features were compared based on LI-RADS categorization. Early recurrence rates (<2 years) and associated factors were also evaluated. Statistical tests: Fisher's exact test, two-sample t test after satisfying assumption of normality through Shapiro-Wilk test, Fleiss κ coefficient, Cox proportional hazards regression analysis, Kaplan-Meier method, and log-rank test. Results: Forty-one HCCs (14.6%) were categorized as LR-M and 240 HCCs (85.4%) were categorized as LR-4/5. LR-M HCCs showed poorer differentiation than LR-4/5 HCCs. In the multivariate analysis, the LR-M category was an independent predictor for early recurrence (hazard ratio, 1.904; 95% confidence interval, 1.024-3.542; P < 0.05). Early recurrence rates were significantly higher in patients with LR-M HCCs than in patients with LR-4/5 HCCs (32.0% vs. 18.4%, respectively, P < 0 05). Data conclusion: Compared to LR-4/5 HCCs, LR-M HCCs were associated with poorer tumor differentiation and higher early recurrence rates after curative resections of single HCCs. Level of evidence: 3 Technical Efficacy Stage: 2. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Liss | - |
dc.relation.isPartOf | JOURNAL OF MAGNETIC RESONANCE IMAGING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Carcinoma, Hepatocellular* / diagnostic imaging | - |
dc.subject.MESH | Contrast Media | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Neoplasms* / diagnostic imaging | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Recurrence, Local / diagnostic imaging | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Characteristics and Early Recurrence of Hepatocellular Carcinomas Categorized as LR-M: Comparison with Those Categorized as LR-4 or 5 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Jaeseung Shin | - |
dc.contributor.googleauthor | Sunyoung Lee | - |
dc.contributor.googleauthor | Seung-Seob Kim | - |
dc.contributor.googleauthor | Yong Eun Chung | - |
dc.contributor.googleauthor | Jin-Young Choi | - |
dc.contributor.googleauthor | Mi-Suk Park | - |
dc.contributor.googleauthor | Myeong-Jin Kim | - |
dc.identifier.doi | 10.1002/jmri.27650 | - |
dc.contributor.localId | A00426 | - |
dc.contributor.localId | A05097 | - |
dc.contributor.localId | A01463 | - |
dc.contributor.localId | A05599 | - |
dc.contributor.localId | A05659 | - |
dc.contributor.localId | A03662 | - |
dc.contributor.localId | A04200 | - |
dc.relation.journalcode | J01567 | - |
dc.identifier.eissn | 1522-2586 | - |
dc.identifier.pmid | 33891790 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/jmri.27650 | - |
dc.subject.keyword | diagnosis | - |
dc.subject.keyword | hepatocellular carcinoma | - |
dc.subject.keyword | magnetic resonance imaging | - |
dc.subject.keyword | prognosis | - |
dc.contributor.alternativeName | Kim, Myeong Jin | - |
dc.contributor.affiliatedAuthor | 김명진 | - |
dc.contributor.affiliatedAuthor | 김승섭 | - |
dc.contributor.affiliatedAuthor | 박미숙 | - |
dc.contributor.affiliatedAuthor | 신재승 | - |
dc.contributor.affiliatedAuthor | 이선영 | - |
dc.contributor.affiliatedAuthor | 정용은 | - |
dc.contributor.affiliatedAuthor | 최진영 | - |
dc.citation.volume | 54 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1446 | - |
dc.citation.endPage | 1454 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol.54(5) : 1446-1454, 2021-11 | - |
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