Fluoxetine 약물치료를 받은 강박장애환자에서 세로토닌 효현제인 MK-212투여에 따른 체온 및 Prolactin 반응의 강화

Abstract

Objects : This study was performed to evaluate the effect of MK-212(6-chloro-2-[1-piperaziny1]-pyrazine), a serotonin agonist, on body temperature and plasma prolactin levels in patients with obsessive-compulsive disorder(OCD) receiving fluoxetine, a selective serotonin reuptake inhibitor. Methods : Body temperature and prolactin responses to the MK-212 and placebo were examined in patients with OCD. A single dose of 20㎎ of MK-212 or placebo were given orally under single-blind, random-assignment conditions to ten subjects before and after 8 weeks fluoxetine treatment. Results : Fluoxetine treatment group showed a significant potentiation in prolactin and body temperature response to MK-212 as compared to an unmedicated state in patients with OCD. Conclusions : These results support the previous hypothesis that OCD may involve the subsensitivity of the 5-HT receptor itself and/or decreased functional activity of the postreceptor signal transduction.