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Fluoxetine 약물치료를 받은 강박장애환자에서 세로토닌 효현제인 MK-212투여에 따른 체온 및 Prolactin 반응의 강화
DC Field | Value | Language |
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dc.contributor.author | 이홍식 | - |
dc.date.accessioned | 2021-12-27T17:25:29Z | - |
dc.date.available | 2021-12-27T17:25:29Z | - |
dc.date.issued | 1995-04 | - |
dc.identifier.issn | 1015-4817 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186632 | - |
dc.description.abstract | Objects : This study was performed to evaluate the effect of MK-212(6-chloro-2-[1-piperaziny1]-pyrazine), a serotonin agonist, on body temperature and plasma prolactin levels in patients with obsessive-compulsive disorder(OCD) receiving fluoxetine, a selective serotonin reuptake inhibitor. Methods : Body temperature and prolactin responses to the MK-212 and placebo were examined in patients with OCD. A single dose of 20㎎ of MK-212 or placebo were given orally under single-blind, random-assignment conditions to ten subjects before and after 8 weeks fluoxetine treatment. Results : Fluoxetine treatment group showed a significant potentiation in prolactin and body temperature response to MK-212 as compared to an unmedicated state in patients with OCD. Conclusions : These results support the previous hypothesis that OCD may involve the subsensitivity of the 5-HT receptor itself and/or decreased functional activity of the postreceptor signal transduction. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한신경정신의학회 | - |
dc.relation.isPartOf | Journal of the Korean Neuropsychiatric Association(신경정신의학) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Fluoxetine 약물치료를 받은 강박장애환자에서 세로토닌 효현제인 MK-212투여에 따른 체온 및 Prolactin 반응의 강화 | - |
dc.title.alternative | Fluoxetine Potentiates Body Temperature and Prolactin Responses to MK-212, A Serotonin Agonist, in Patients with Obsessive-Compulsive Disorder | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학교실) | - |
dc.contributor.googleauthor | 이홍식 | - |
dc.contributor.googleauthor | 김찬형 | - |
dc.contributor.googleauthor | 송동호 | - |
dc.contributor.localId | A03332 | - |
dc.relation.journalcode | J01837 | - |
dc.subject.keyword | MK-212 | - |
dc.subject.keyword | Prolactin response | - |
dc.subject.keyword | Fluoxetine | - |
dc.subject.keyword | Body temperature | - |
dc.subject.keyword | Obsessive-compulsive disorder | - |
dc.contributor.alternativeName | Lee, Hong Shick | - |
dc.contributor.affiliatedAuthor | 이홍식 | - |
dc.citation.volume | 34 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 557 | - |
dc.citation.endPage | 563 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Neuropsychiatric Association (신경정신의학), Vol.34(2) : 557-563, 1995-04 | - |
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