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백서에서 Bleomycin 투여로 인한 폐손상 및 폐섬유화에 대한 Vitamin E의 영향 -Penicillalnine, Deferoxamine 투여군과 비교-

Other Titles
 The Effect of Vitamin E on Bleomycin-Induced Pulmonary Injury and Fibrosis in Hat -Comparison of Penicillamine- or Deferoxamine-Treated Group- 
Authors
 정순희  ;  용석중  ;  신계철  ;  안철민  ;  최인준  ;  조상호 
Citation
 Tuberculosis and Respiratory Diseases (결핵 및 호흡기질환), Vol.42(2) : 184-205, 41995-05 
Journal Title
TUBERCULOSIS AND RESPIRATORY DISEASES(결핵 및 호흡기질환)
ISSN
 0378-006 
Issue Date
4199-05-05
Keywords
Bleomycin ; Pulmonary injury ; Vitamin E ; Oxygen radicals ; Extracellular matrix
Abstract
Background: Pulmonary toxicity by bleomycia has multiple mechanisms including direct tissue toxicity due to oxygen-derived free radicals and indirect toxicity through amplification of pulmonary inflammation. To evaluate the effect of chelators or free radical scavenger to lung damage induced by bleomycin, penicillamine as a copper chelator, deferoxamine as an iron chelator and vitamin E as a free radical scavenger were administered.
Methods: Two hundred Wistar rats were divided into five groups: Control, bleomycin treated, bleomycin-penicillamine treated, bleomycin-deferoxamine treated, and
bleomycin-vitamin E treated groups. Rats sacrificed on day 1, day 3, day 4, day 7, day 14, and day 28 after treatment. Bronchoalveolar lavage, light microscopic and
immunohistologic studies (or type Ⅰ, Ⅲ, Ⅳ collagens, fibronectin, laminin and NBD phallicidin were evaluated.
Results: There was a significant increase in the total cell counts of bronchoalveolar lavage on day 1 from all treated animals and vitamin treated group showed an abrupt decrease in total cell counts with decrease of neutrophils on day 3. Bleomycin-vitamin I
treated group had the least histologic changes such as pulmonary fibrosis. The alveolar basement membranes were positive for type Ⅳ collagen and laminin. Basement membranes of bleomycin, bleomycin-penicillamine, or bleomycin-deferoxamine treated
groups were disrupted and fragmented on day 4 or 7. The bleomycin-vitamin E treated
group odd intact basement membranes until day 28. Conclusion: Bleomycin-inducted pulmonary fibrosis was related to the severity of
acute injury to oxygen radicals or activation of neutrophils and disruption of basement membrane. Vitamin E seemed to be the most effective antioxidant in the inhibition of
bleomycin-induced pulmonary injury and fibrosis.
Files in This Item:
T199502062.pdf Download
DOI
10.4046/trd.1995.42.2.184
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Chul Min(안철민)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/186617
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