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Fluoxetine 약물치료를 받은 강박장애환자에서 세로토닌 효현제인 MK-212투여에 따른 체온 및 Prolactin 반응의 강화

Other Titles
 Fluoxetine Potentiates Body Temperature and Prolactin Responses to MK-212, A Serotonin Agonist, in Patients with Obsessive-Compulsive Disorder 
Authors
 이홍식  ;  김찬형  ;  송동호 
Citation
 Journal of the Korean Neuropsychiatric Association (신경정신의학), Vol.34(2) : 557-563, 1995-04 
Journal Title
Journal of the Korean Neuropsychiatric Association(신경정신의학)
ISSN
 1015-4817 
Issue Date
1995-04
Keywords
MK-212 ; Prolactin response ; Fluoxetine ; Body temperature ; Obsessive-compulsive disorder
Abstract
Objects : This study was performed to evaluate the effect of MK-212(6-chloro-2-[1-piperaziny1]-pyrazine), a serotonin agonist, on body temperature and plasma prolactin levels in patients with obsessive-compulsive disorder(OCD) receiving fluoxetine, a selective serotonin reuptake inhibitor.
Methods : Body temperature and prolactin responses to the MK-212 and placebo were examined in patients with OCD. A single dose of 20㎎ of MK-212 or placebo were given orally under single-blind, random-assignment conditions to ten subjects before and after 8 weeks fluoxetine treatment.
Results : Fluoxetine treatment group showed a significant potentiation in prolactin and body temperature response to MK-212 as compared to an unmedicated state in patients with OCD.
Conclusions : These results support the previous hypothesis that OCD may involve the subsensitivity of the 5-HT receptor itself and/or decreased functional activity of the postreceptor signal transduction.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chan Hyung(김찬형)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/186087
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