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Comparing different types of statins for secondary prevention of cardio-cerebrovascular disease from a national cohort study
DC Field | Value | Language |
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dc.contributor.author | 김정연 | - |
dc.date.accessioned | 2021-10-21T00:17:29Z | - |
dc.date.available | 2021-10-21T00:17:29Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/185461 | - |
dc.description.abstract | Statins have been recommended for use in atherosclerotic cardio-cerebrovascular disease (CCVD). The purpose of this study was to investigate the efficacy of five different types of statin in the secondary prevention of CCVD in patients. This study retrospectively designed and analyzed data from the National Health Insurance Service-National Health in Korea. Participants aged 40 to 69 years were categorized into five statin groups (atorvastatin, rosuvastatin, pitavastatin, simvastatin, and pravastatin). The primary composite outcome was defined as recurrence of CCVD or all causes of death. Cox proportional hazard regression models were adopted after stepwise adjustments for confounders to investigate the difference in efficacy among the different statins. Of the 755 final participants, 48 patients experienced primary composite outcomes. After adjustments, the hazard ratios (95% confidence intervals) for primary composite outcomes of atorvastatin, pitavastatin, and rosuvastatin groups were 0.956 (0.456-2.005), 1.347 (0.354-5.116), and 0.943 (0.317-2.803), respectively, when compared with the simvastatin group. There were no significant differences between the statins in efficacy for preventing recurrence of CCVD events and/or death in CCVD patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Cardiovascular Diseases / prevention & control* | - |
dc.subject.MESH | Cerebrovascular Disorders / prevention & control* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Secondary Prevention / statistics & numerical data* | - |
dc.title | Comparing different types of statins for secondary prevention of cardio-cerebrovascular disease from a national cohort study | - |
dc.type | Article | - |
dc.contributor.college | College of Nursing (간호대학) | - |
dc.contributor.department | Dept. of Nursing (간호학과) | - |
dc.contributor.googleauthor | Joungyoun Kim | - |
dc.contributor.googleauthor | Hyeong-Seop Kim | - |
dc.contributor.googleauthor | Yun-Jong Bae | - |
dc.contributor.googleauthor | Hyeong-Chul Lee | - |
dc.contributor.googleauthor | Jae-Woo Lee | - |
dc.contributor.googleauthor | Hee-Taik Kang | - |
dc.identifier.doi | 10.1371/journal.pone.0247419 | - |
dc.contributor.localId | A06089 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 33630898 | - |
dc.contributor.alternativeName | Joungyoun Kim | - |
dc.contributor.affiliatedAuthor | 김정연 | - |
dc.citation.volume | 16 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | e0247419 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.16(2) : e0247419, 2021-02 | - |
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