Cited 8 times in
Liver Imaging Reporting and Data System Category on Magnetic Resonance Imaging Predicts Recurrence of Hepatocellular Carcinoma After Liver Transplantation Within the Milan Criteria: A Multicenter Study
DC Field | Value | Language |
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dc.contributor.author | 이선영 | - |
dc.contributor.author | 최진섭 | - |
dc.date.accessioned | 2021-10-21T00:15:51Z | - |
dc.date.available | 2021-10-21T00:15:51Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 1068-9265 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/185446 | - |
dc.description.abstract | Background: This study was designed to investigate the association between Liver Imaging Reporting and Data System (LI-RADS) category and recurrence of hepatocellular carcinoma (HCC) after primary liver transplantation (LT) within the Milan criteria. Methods: This multicenter, retrospective study included 140 recipients who underwent living donor LT (LDLT) for treatment-naïve HCC and pretransplant contrast-enhanced magnetic resonance imaging (MRI) between 2009 and 2013. LI-RADS categories were assigned using LI-RADS version 2018. Recurrence-free survival (RFS) and associated factors were evaluated using Cox proportional hazards regression analysis, Kaplan-Meier analysis, and log-rank test. Histological grading and microvascular invasion (MVI) were analyzed on the pathologic examinations of explanted livers. Results: The overall 1-, 3-, 5-, and 7-year RFS rates were 95.6%, 92.6%, 90.2%, and 89.3%, respectively. In the multivariable analysis, independent predictors of recurrence included HCCs categorized as LR-M (hazard ratio [HR], 18.68; 95% confidence interval [CI], 5.79-60.23; P < 0.001) and the largest tumor size of ≥ 3 cm on MRI (HR, 4.18; 95% CI, 1.42-12.37; P = 0.010). The 5-year RFS rate was significantly lower in patients with HCCs categorized as LR-M than in those with HCCs categorized as LR-5 or 4 (LR-5/4) (36.9% vs. 95.8%, respectively; P < 0.001). HCCs categorized as LR-M exhibited significantly more MVI than HCCs categorized as LR-5/4 (57.1% vs. 17.5%, respectively; P = 0.002). Conclusions: Patients with HCCs categorized as LR-M using LI-RADS version 2018 may have a worse prognosis after primary LT within the Milan criteria than those with HCCs categorized as LR-5/4. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | ANNALS OF SURGICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Carcinoma, Hepatocellular* / diagnostic imaging | - |
dc.subject.MESH | Carcinoma, Hepatocellular* / surgery | - |
dc.subject.MESH | Contrast Media | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Neoplasms* / diagnostic imaging | - |
dc.subject.MESH | Liver Neoplasms* / surgery | - |
dc.subject.MESH | Liver Transplantation* | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Neoplasm Recurrence, Local / diagnostic imaging | - |
dc.subject.MESH | Neoplasm Recurrence, Local / surgery | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Liver Imaging Reporting and Data System Category on Magnetic Resonance Imaging Predicts Recurrence of Hepatocellular Carcinoma After Liver Transplantation Within the Milan Criteria: A Multicenter Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Sunyoung Lee | - |
dc.contributor.googleauthor | Kyoung Won Kim | - |
dc.contributor.googleauthor | Woo Kyoung Jeong | - |
dc.contributor.googleauthor | So Yeong Jeong | - |
dc.contributor.googleauthor | Jeong Ah Hwang | - |
dc.contributor.googleauthor | Jin Sub Choi | - |
dc.contributor.googleauthor | Sung-Gyu Lee | - |
dc.contributor.googleauthor | Jae-Won Joh | - |
dc.identifier.doi | 10.1245/s10434-021-09772-8 | - |
dc.contributor.localId | A05659 | - |
dc.contributor.localId | A04199 | - |
dc.relation.journalcode | J00179 | - |
dc.identifier.eissn | 1534-4681 | - |
dc.identifier.pmid | 33751296 | - |
dc.identifier.url | https://link.springer.com/article/10.1245%2Fs10434-021-09772-8 | - |
dc.contributor.alternativeName | Lee, Sunyoung | - |
dc.contributor.affiliatedAuthor | 이선영 | - |
dc.contributor.affiliatedAuthor | 최진섭 | - |
dc.citation.volume | 28 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 6782 | - |
dc.citation.endPage | 6789 | - |
dc.identifier.bibliographicCitation | ANNALS OF SURGICAL ONCOLOGY, Vol.28(11) : 6782-6789, 2021-10 | - |
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