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Liver Imaging Reporting and Data System Category on Magnetic Resonance Imaging Predicts Recurrence of Hepatocellular Carcinoma After Liver Transplantation Within the Milan Criteria: A Multicenter Study

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dc.contributor.author이선영-
dc.contributor.author최진섭-
dc.date.accessioned2021-10-21T00:15:51Z-
dc.date.available2021-10-21T00:15:51Z-
dc.date.issued2021-10-
dc.identifier.issn1068-9265-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/185446-
dc.description.abstractBackground: This study was designed to investigate the association between Liver Imaging Reporting and Data System (LI-RADS) category and recurrence of hepatocellular carcinoma (HCC) after primary liver transplantation (LT) within the Milan criteria. Methods: This multicenter, retrospective study included 140 recipients who underwent living donor LT (LDLT) for treatment-naïve HCC and pretransplant contrast-enhanced magnetic resonance imaging (MRI) between 2009 and 2013. LI-RADS categories were assigned using LI-RADS version 2018. Recurrence-free survival (RFS) and associated factors were evaluated using Cox proportional hazards regression analysis, Kaplan-Meier analysis, and log-rank test. Histological grading and microvascular invasion (MVI) were analyzed on the pathologic examinations of explanted livers. Results: The overall 1-, 3-, 5-, and 7-year RFS rates were 95.6%, 92.6%, 90.2%, and 89.3%, respectively. In the multivariable analysis, independent predictors of recurrence included HCCs categorized as LR-M (hazard ratio [HR], 18.68; 95% confidence interval [CI], 5.79-60.23; P < 0.001) and the largest tumor size of ≥ 3 cm on MRI (HR, 4.18; 95% CI, 1.42-12.37; P = 0.010). The 5-year RFS rate was significantly lower in patients with HCCs categorized as LR-M than in those with HCCs categorized as LR-5 or 4 (LR-5/4) (36.9% vs. 95.8%, respectively; P < 0.001). HCCs categorized as LR-M exhibited significantly more MVI than HCCs categorized as LR-5/4 (57.1% vs. 17.5%, respectively; P = 0.002). Conclusions: Patients with HCCs categorized as LR-M using LI-RADS version 2018 may have a worse prognosis after primary LT within the Milan criteria than those with HCCs categorized as LR-5/4.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer-
dc.relation.isPartOfANNALS OF SURGICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHCarcinoma, Hepatocellular* / diagnostic imaging-
dc.subject.MESHCarcinoma, Hepatocellular* / surgery-
dc.subject.MESHContrast Media-
dc.subject.MESHHumans-
dc.subject.MESHLiver Neoplasms* / diagnostic imaging-
dc.subject.MESHLiver Neoplasms* / surgery-
dc.subject.MESHLiver Transplantation*-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHNeoplasm Recurrence, Local / diagnostic imaging-
dc.subject.MESHNeoplasm Recurrence, Local / surgery-
dc.subject.MESHRetrospective Studies-
dc.titleLiver Imaging Reporting and Data System Category on Magnetic Resonance Imaging Predicts Recurrence of Hepatocellular Carcinoma After Liver Transplantation Within the Milan Criteria: A Multicenter Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorSunyoung Lee-
dc.contributor.googleauthorKyoung Won Kim-
dc.contributor.googleauthorWoo Kyoung Jeong-
dc.contributor.googleauthorSo Yeong Jeong-
dc.contributor.googleauthorJeong Ah Hwang-
dc.contributor.googleauthorJin Sub Choi-
dc.contributor.googleauthorSung-Gyu Lee-
dc.contributor.googleauthorJae-Won Joh-
dc.identifier.doi10.1245/s10434-021-09772-8-
dc.contributor.localIdA05659-
dc.contributor.localIdA04199-
dc.relation.journalcodeJ00179-
dc.identifier.eissn1534-4681-
dc.identifier.pmid33751296-
dc.identifier.urlhttps://link.springer.com/article/10.1245%2Fs10434-021-09772-8-
dc.contributor.alternativeNameLee, Sunyoung-
dc.contributor.affiliatedAuthor이선영-
dc.contributor.affiliatedAuthor최진섭-
dc.citation.volume28-
dc.citation.number11-
dc.citation.startPage6782-
dc.citation.endPage6789-
dc.identifier.bibliographicCitationANNALS OF SURGICAL ONCOLOGY, Vol.28(11) : 6782-6789, 2021-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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