Cited 3 times in
Hepatobiliary phase signal intensity: A potential method of diagnosing HCC with atypical imaging features among LR-M observations
DC Field | Value | Language |
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dc.contributor.author | 정용은 | - |
dc.contributor.author | 서니은 | - |
dc.contributor.author | 최진영 | - |
dc.contributor.author | 박미숙 | - |
dc.contributor.author | 김명진 | - |
dc.date.accessioned | 2021-09-29T05:33:46Z | - |
dc.date.available | 2021-09-29T05:33:46Z | - |
dc.date.issued | 2021-09 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/185100 | - |
dc.description.abstract | Herein, we assessed whether hepatobiliary phase (HBP) signal intensity (SI) can be used to differentiate HCC and non-HCC malignancies within LR-M observations. 106 LR-M patients based on LI-RADS v2018 who underwent gadoxetate-disodium magnetic resonance imaging and surgery from January 2009 to December 2018 were included. SI of LR-M observation on HBP was analyzed by two radiologists and categorized into dark, low and iso-to-high groups. Tumor was classified as dark when more than 50% of tumor showed hypointensity compared to spleen, as low when more than 50% of tumor showed hyperintensity compared to spleen but hypointensity compared to liver parenchyma, and as iso-to-high if there was even a focal iso-intensity or hyperintensity compared to liver parenchyma. Analysis of clinicopathological factors and association between imaging and histology was performed. Out of 106 LR-M, 42 (40%) were showed dark, 61 (58%) showed low, and 3 (3%) showed iso-to-high SI in HBP. Three iso-to-high SI LR-M were HCCs (P = 0.060) and their major histologic differentiation was Edmondson grade 1 (P = 0.001). 43 out of 61 (71%) low SI LR-M were iCCA or cHCC-CCA (P = 0.002). Inter-reader agreement of HBP SI classification was excellent, with a kappa coefficient of 0.872. LR-M with iso-to-high SI in HBP is prone to being HCC while LR-M with low SI in HBP is prone to being tumor with fibrous stroma such as iCCA and cHCC-CCA. Classification of LR-M based on HBP SI may be a helpful method of differentiating HCC from non-HCC malignancies. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Hepatobiliary phase signal intensity: A potential method of diagnosing HCC with atypical imaging features among LR-M observations | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Jae Hyon Park | - |
dc.contributor.googleauthor | Yong Eun Chung | - |
dc.contributor.googleauthor | Nieun Seo | - |
dc.contributor.googleauthor | Jin-Young Choi | - |
dc.contributor.googleauthor | Mi-Suk Park | - |
dc.contributor.googleauthor | Myeong-Jin Kim | - |
dc.identifier.doi | 10.1371/journal.pone.0257308 | - |
dc.contributor.localId | A03662 | - |
dc.contributor.localId | A01874 | - |
dc.contributor.localId | A04200 | - |
dc.contributor.localId | A01463 | - |
dc.contributor.localId | A00426 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 34516587 | - |
dc.contributor.alternativeName | Chung, Yong Eun | - |
dc.contributor.affiliatedAuthor | 정용은 | - |
dc.contributor.affiliatedAuthor | 서니은 | - |
dc.contributor.affiliatedAuthor | 최진영 | - |
dc.contributor.affiliatedAuthor | 박미숙 | - |
dc.contributor.affiliatedAuthor | 김명진 | - |
dc.citation.volume | 16 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | e0257308 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.16(9) : e0257308, 2021-09 | - |
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