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The Protective Effect of an Eye Wash Solution on the Ocular Surface Damage Induced by Airborne Carbon Black Exposure

Authors
 Xiangzhe Li  ;  Boram Kang  ;  Youngsub Eom  ;  Hyung Keun Lee  ;  Hyo Myung Kim  ;  Jong Suk Song 
Citation
 CORNEA, Vol.39(8) : 1040-1047, 2020-08 
Journal Title
CORNEA
ISSN
 0277-3740 
Issue Date
2020-08
MeSH
Animals ; Blotting, Western ; Disease Models, Animal ; Dry Eye Syndromes / chemically induced ; Dry Eye Syndromes / metabolism ; Dry Eye Syndromes / prevention & control ; Enzyme-Linked Immunosorbent Assay ; Male ; Ophthalmic Solutions / pharmacology* ; Particulate Matter / adverse effects* ; Rats ; Rats, Sprague-Dawley ; Soot / adverse effects* ; Tears / metabolism*
Abstract
Purpose: To investigate the effects of an eye wash solution on the ocular surface damage induced by airborne carbon black (CB) exposure.

Methods: Sprague-Dawley rats were exposed to ambient CB for 5 days. During the 5 days, a commercial eye wash solution (Eyebon-W) was used for irrigation twice daily on CB-exposed rat eyes; normal saline was used as the vehicle control. Lactic dehydrogenase (LDH) activity and matrix metallopeptidase (MMP)-9, histamine, and lactoferrin levels were measured in tears. The expression of inflammatory cytokines in the anterior segment of the eyeball was measured by Western blot analysis.

Results: The ocular surface staining scores, tear LDH activity, tear MMP-9, histamine, and lactoferrin concentrations, and the expression of interleukin-4 and interferon-γ in the eye were significantly increased in the CB group versus the normal control group. When compared with CB group, the Eyebon-W eye wash treatment significantly reversed these elevations induced by CB, including ocular staining scores, tear LDH activity, histamine and MMP-9 concentrations in the tear fluid, and the expression of interleukin-4 in the eye. On the other hand, saline irrigation only reduced the concentrations of histamine and MMP-9 in tear fluid and the expression of interferon-γ in the eye.

Conclusions: Both Eyebon-W eye wash treatment and saline irrigation reversed CB-induced ocular surface injury, but the efficacy of Eyebon-W was more significant than that of the saline solution when compared with CB group. The use of an eye wash solution seems to play a protective role for the ocular surface when exposed to airborne particulate matter.
Full Text
https://journals.lww.com/corneajrnl/Fulltext/2020/08000/The_Protective_Effect_of_an_Eye_Wash_Solution_on.19.aspx
DOI
10.1097/ICO.0000000000002304
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Hyung Keun(이형근) ORCID logo https://orcid.org/0000-0002-1123-2136
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/185002
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