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Surgical approach for the treatment of thymic carcinoma: 201 cases from a multi-institutional study

Authors
 Yeong Jeong Jeon  ;  Yong Soo Choi  ;  Jong Ho Cho  ;  Hong Kwan Kim  ;  Geun Dong Lee  ;  Dong Kwan Kim  ;  Chang Hyun Kang  ;  Young Tae Kim  ;  Chang Young Lee  ;  Jin Gu Lee 
Citation
 PRECISION AND FUTURE MEDICINE, Vol.4(4) : 149-160, 2020-12 
Journal Title
PRECISION AND FUTURE MEDICINE
ISSN
 2508-7940 
Issue Date
2020-12
Keywords
Thymus neoplasms ; Carcinoma ; Thoracic surgery, video-assisted
Abstract
Purpose: This study aimed to compare the outcomes of surgical approach (video-as sisted thoracoscopic surgery [VATS] vs. sternotomy vs. thoracotomy) for the treatment ofthymic carcinoma Methods: We retrospectively reviewed 201 patients with pathologically proven thymic carcinoma who underwent surgicalresection atfour Korean institutions. Results: From 2007 to 2013, 158 sternotomy, 33 VATS and 10 thoracotomy were con ducted forthymic carcinoma. Open group underwent more preoperative biopsy (41.8% and 50% vs. 15.2%, P=0.012) and neoadjuvant treatment (22.2% and 30% vs. 0%, P=0.008) than VATS group. In preoperative imaging, tumor size of VATS group was smaller than sternotomy group (3.8±1.1 cm vs. 5.8±2 cm, P<0.05) and 91% of the VATS group was clinicaltumor-node-metastasis (TNM) stage I. The lengths of chesttube and mechanical ventilation duration, postoperative hospital day and intensive care unit stay were shorterin VATS group than open group (P<0.001). The incidence of postoper ative complications of VATS group was lower than sternotomy group (P=0.014). The 5-year overall survival of the sternotomy, VATS and thoracotomy group were 100%, 100% and 87.5%±11.7%, respectively (P=0.107). The 5-year recurrence-free survival rate was not significantly different between the groups (55.4%±4.5%, 67.9%±12.1%, and 87.5%±11.7%; P=0.131) Conclusion: The VATS approach of surgical treatment for thymic carcinoma can be se lectively employed in small (<5 cm) and TNM stage I tumor without compromise of on cologic outcome
Files in This Item:
T999202288.pdf Download
DOI
10.23838/pfm.2020.00163
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jin Gu(이진구)
Lee, Chang Young(이창영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184992
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