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Therapeutic Strategies for Diabetes: Immune Modulation in Pancreatic β Cells

Authors
 Sugyeong Jo  ;  Sungsoon Fang 
Citation
 FRONTIERS IN ENDOCRINOLOGY, Vol.12 : 716692, 2021-08 
Journal Title
FRONTIERS IN ENDOCRINOLOGY
Issue Date
2021-08
Keywords
autoimmunity ; diabetes ; gut microbiota ; immune modulation ; inflammation ; pancreatic β cell
Abstract
Increased incidence of type I and type II diabetes has been prevailed worldwide. Though the pathogenesis of molecular mechanisms remains still unclear, there are solid evidence that disturbed immune homeostasis leads to pancreatic β cell failure. Currently, autoimmunity and uncontrolled inflammatory signaling pathways have been considered the major factors in the pathogenesis of diabetes. Many components of immune system have been reported to implicate pancreatic β cell failure, including helper T cells, cytotoxic T cells, regulatory T cells and gut microbiota. Immune modulation of those components using small molecules and antibodies, and fecal microbiota transplantation are undergoing in many clinical trials for the treatment of type I and type II diabetes. In this review we will discuss the basis of molecular pathogenesis focusing on the disturbed immune homeostasis in type I and type II diabetes, leading to pancreatic β cell destruction. Finally, we will introduce current therapeutic strategies and clinical trials by modulation of immune system for the treatment of type I and type II diabetes patients.
Files in This Item:
T202103916.pdf Download
DOI
10.3389/fendo.2021.716692
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Fang, Sungsoon(황성순) ORCID logo https://orcid.org/0000-0003-0201-5567
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184874
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