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A multicenter comparison of [ 18 F]flortaucipir, [ 18 F]RO948, and [ 18 F]MK6240 tau PET tracers to detect a common target ROI for differential diagnosis

Authors
 Antoine Leuzy  ;  Tharick A Pascoal  ;  Olof Strandberg  ;  Philip Insel  ;  Ruben Smith  ;  Niklas Mattsson-Carlgren  ;  Andréa L Benedet  ;  Hannah Cho  ;  Chul H Lyoo  ;  Renaud La Joie  ;  Gil D Rabinovici  ;  Rik Ossenkoppele  ;  Pedro Rosa-Neto  ;  Oskar Hansson 
Citation
 EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol.48(7) : 2295-2305, 2021-07 
Journal Title
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
ISSN
 1619-7070 
Issue Date
2021-07
MeSH
Alzheimer Disease* / diagnostic imaging ; Carbolines ; Cognitive Dysfunction* ; Diagnosis, Differential ; Humans ; Positron-Emission Tomography ; tau Proteins
Keywords
PET ; Tau ; [18F]Flortaucipir ; [18F]MK6240 ; [18F]RO948
Abstract
Purpose: This study aims to determine whether comparable target regions of interest (ROIs) and cut-offs can be used across [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau positron emission tomography (PET) tracers for differential diagnosis of Alzheimer's disease (AD) dementia vs either cognitively unimpaired (CU) individuals or non-AD neurodegenerative diseases. Methods: A total of 1755 participants underwent tau PET using either [18F]flortaucipir (n = 975), [18F]RO948 (n = 493), or [18F]MK6240 (n = 287). SUVR values were calculated across four theory-driven ROIs and several tracer-specific data-driven (hierarchical clustering) regions of interest (ROIs). Diagnostic performance and cut-offs for ROIs were determined using receiver operating characteristic analyses and the Youden index, respectively. Results: Comparable diagnostic performance (area under the receiver operating characteristic curve [AUC]) was observed between theory- and data-driven ROIs. The theory-defined temporal meta-ROI generally performed very well for all three tracers (AUCs: 0.926-0.996). An SUVR value of approximately 1.35 was a common threshold when using this ROI. Conclusion: The temporal meta-ROI can be used for differential diagnosis of dementia patients with [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau PET with high accuracy, and that using very similar cut-offs of around 1.35 SUVR. This ROI/SUVR cut-off can also be applied across tracers to define tau positivity.
Files in This Item:
T202103801.pdf Download
DOI
10.1007/s00259-021-05401-4
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
Cho, Hanna(조한나) ORCID logo https://orcid.org/0000-0001-5936-1546
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184827
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